TY - JOUR
T1 - Nasal inhalation challenge studies with sidestream tobacco smoke
AU - Bascom, Rebecca
AU - Willes, Stuart R.
AU - Fitzgerald, Thomas K.
N1 - Funding Information:
This study was supported, in part, by the American Lung Association of Maryland (SRW) and by NHLBI grant number 5R29HL40945-02 (RBI. Submitted for publication December 30, 1990; revised; accepted for publication September 20, 1991. Requests for reprints should be sent to Rebecca Baxom, M.D., M.P.H., MSTFBOO, 10 S. Pine Street, Baltimore, MD 21201.
PY - 1992
Y1 - 1992
N2 - Environmental tobacco smoke (ETS) exposure is associated with rhinitis symptoms (i.e., runny nose and congestion) in some people. In an effort to better understand these symptoms, we recruited 18 historically ETS-sensitive subjects from the community and exposed them for 15 min to clean air and for 15 min to sidestream tobacco smoke (STS, 45 ppm carbon monoxide). Symptoms were recorded (0 = absent, 5 = severe), and posterior rhinomanometry was performed. There were significant changes in rhinitis symptoms (1.3 ± 0.4 pre- versus 6.1 ± 0.5 post-STS, p <.05); nasal airway resistance (2.86 ± 0.2 pre- versus 4.49 ± 0.6 post-STS, p <.05), and maximum inspiratory flow (2.74 ± 0.3 pre- versus 2.14 ± 0.3 post-STS, p <.05). A spectrum of individual responsiveness to ETS was observed, and nasal resistance increased from 0% to 265%. Increased nasal resistance occurred primarily at the upstream or flow-limiting segment of the nasal airway.
AB - Environmental tobacco smoke (ETS) exposure is associated with rhinitis symptoms (i.e., runny nose and congestion) in some people. In an effort to better understand these symptoms, we recruited 18 historically ETS-sensitive subjects from the community and exposed them for 15 min to clean air and for 15 min to sidestream tobacco smoke (STS, 45 ppm carbon monoxide). Symptoms were recorded (0 = absent, 5 = severe), and posterior rhinomanometry was performed. There were significant changes in rhinitis symptoms (1.3 ± 0.4 pre- versus 6.1 ± 0.5 post-STS, p <.05); nasal airway resistance (2.86 ± 0.2 pre- versus 4.49 ± 0.6 post-STS, p <.05), and maximum inspiratory flow (2.74 ± 0.3 pre- versus 2.14 ± 0.3 post-STS, p <.05). A spectrum of individual responsiveness to ETS was observed, and nasal resistance increased from 0% to 265%. Increased nasal resistance occurred primarily at the upstream or flow-limiting segment of the nasal airway.
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U2 - 10.1080/00039896.1992.9938353
DO - 10.1080/00039896.1992.9938353
M3 - Article
C2 - 1596106
AN - SCOPUS:0026691649
SN - 0003-9896
VL - 47
SP - 223
EP - 230
JO - Archives of Environmental Health
JF - Archives of Environmental Health
IS - 3
ER -
