Nasal inhalation challenge studies with sidestream tobacco smoke

Rebecca Bascom, Stuart R. Willes, Thomas K. Fitzgerald

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Environmental tobacco smoke (ETS) exposure is associated with rhinitis symptoms (i.e., runny nose and congestion) in some people. In an effort to better understand these symptoms, we recruited 18 historically ETS-sensitive subjects from the community and exposed them for 15 min to clean air and for 15 min to sidestream tobacco smoke (STS, 45 ppm carbon monoxide). Symptoms were recorded (0 = absent, 5 = severe), and posterior rhinomanometry was performed. There were significant changes in rhinitis symptoms (1.3 ± 0.4 pre- versus 6.1 ± 0.5 post-STS, p <.05); nasal airway resistance (2.86 ± 0.2 pre- versus 4.49 ± 0.6 post-STS, p <.05), and maximum inspiratory flow (2.74 ± 0.3 pre- versus 2.14 ± 0.3 post-STS, p <.05). A spectrum of individual responsiveness to ETS was observed, and nasal resistance increased from 0% to 265%. Increased nasal resistance occurred primarily at the upstream or flow-limiting segment of the nasal airway.

Original languageEnglish (US)
Pages (from-to)223-230
Number of pages8
JournalArchives of Environmental Health
Issue number3
StatePublished - 1992

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • General Environmental Science
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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