TY - JOUR
T1 - Natural killer T cells
T2 - Rapid responders controlling immunity and disease
AU - Mercer, Jason C.
AU - Ragin, Melanie J.
AU - August, Avery
N1 - Funding Information:
We would like to thank the members of the August lab for fruitful discussions. Apologies are extended to all those investigators working in the field whose work we could not cite or adequately discuss due to space constraints. The work in the August lab is supported by grants from the Johnson & Johnson Focused Giving Program, the American Heart Association (award # 0330036N) and the NIH (RO1-AI51626) (all to A.A.). M.J.R. is supported by a Minority Supplement to grant RO1-AI51626, and is a Sloan Foundation Fellow.
PY - 2005/7
Y1 - 2005/7
N2 - Natural killer T (NKT) cells are a subset of T cells that share properties of natural killer cells and conventional T cells. They are involved in immediate immune responses, tumor rejection, immune surveillance and control of autoimmune diseases. Most NKT cells express both an invariant T cell antigen receptor and the NK cell receptor NK1.1, and are referred to as invariant NKT cells. This invariant T cell receptor is restricted to interactions with glycolipids presented by the non-classical MHC, CD1d. These NKT cells rapidly produce high levels of interleukin (IL)-2, IFN-γ, TNF-α, and IL-4 upon stimulation through their TCR. Most also have cytotoxic activity similar to NK cells. NKT cells are involved in a number of pathological conditions, and have been shown to regulate viral infections in vivo, and control tumor growth. They may also play both protective and harmful roles in the progression of certain autoimmune diseases, such as diabetes, lupus, atherosclerosis, and allergen-induced asthma.
AB - Natural killer T (NKT) cells are a subset of T cells that share properties of natural killer cells and conventional T cells. They are involved in immediate immune responses, tumor rejection, immune surveillance and control of autoimmune diseases. Most NKT cells express both an invariant T cell antigen receptor and the NK cell receptor NK1.1, and are referred to as invariant NKT cells. This invariant T cell receptor is restricted to interactions with glycolipids presented by the non-classical MHC, CD1d. These NKT cells rapidly produce high levels of interleukin (IL)-2, IFN-γ, TNF-α, and IL-4 upon stimulation through their TCR. Most also have cytotoxic activity similar to NK cells. NKT cells are involved in a number of pathological conditions, and have been shown to regulate viral infections in vivo, and control tumor growth. They may also play both protective and harmful roles in the progression of certain autoimmune diseases, such as diabetes, lupus, atherosclerosis, and allergen-induced asthma.
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U2 - 10.1016/j.biocel.2004.11.019
DO - 10.1016/j.biocel.2004.11.019
M3 - Short survey
C2 - 15833265
AN - SCOPUS:17044409102
SN - 1357-2725
VL - 37
SP - 1337
EP - 1343
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 7
ER -