TY - JOUR
T1 - Near infrared (NIR) strong field ionization and imaging of C60 sputtered molecules
T2 - Overcoming matrix effects and improving sensitivity
AU - Kucher, Andrew
AU - Jackson, Lauren M.
AU - Lerach, Jordan O.
AU - Bloom, A. N.
AU - Popczun, N. J.
AU - Wucher, Andreas
AU - Winograd, Nicholas
PY - 2014/9/2
Y1 - 2014/9/2
N2 - Strong field ionization (SFI) was applied for the secondary neutral mass spectrometry (SNMS) of patterned rubrene films, mouse brain sections, and Botryococcus braunii algal cell colonies. Molecular ions of rubrene, cholesterol, C31 diene/triene, and three wax monoesters were detected, representing some of the largest organic molecules ever ionized intact by a laser post-ionization experiment. In rubrene, the SFI SNMS molecular ion signal was ∼4 times higher than in the corresponding secondary-ion mass spectroscopy (SIMS) analysis. In the biological samples, the achieved signal improvements varied among molecules and sampling locations, with SFI SNMS, in some cases, revealing analytes made completely undetectable by the influence of matrix effects in SIMS.
AB - Strong field ionization (SFI) was applied for the secondary neutral mass spectrometry (SNMS) of patterned rubrene films, mouse brain sections, and Botryococcus braunii algal cell colonies. Molecular ions of rubrene, cholesterol, C31 diene/triene, and three wax monoesters were detected, representing some of the largest organic molecules ever ionized intact by a laser post-ionization experiment. In rubrene, the SFI SNMS molecular ion signal was ∼4 times higher than in the corresponding secondary-ion mass spectroscopy (SIMS) analysis. In the biological samples, the achieved signal improvements varied among molecules and sampling locations, with SFI SNMS, in some cases, revealing analytes made completely undetectable by the influence of matrix effects in SIMS.
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U2 - 10.1021/ac501586d
DO - 10.1021/ac501586d
M3 - Article
C2 - 25109240
AN - SCOPUS:84906875663
SN - 0003-2700
VL - 86
SP - 8613
EP - 8620
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 17
ER -