TY - JOUR
T1 - Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription
AU - Natarajan, Malini
AU - Schiralli Lester, Gillian M.
AU - Lee, Chanhyo
AU - Missra, Anamika
AU - Wasserman, Gregory A.
AU - Steffen, Martin
AU - Gilmour, David S.
AU - Henderson, Andrew J.
PY - 2013/9/6
Y1 - 2013/9/6
N2 - Background: Multiple mechanisms contribute to HIV latency, including NELF-mediated RNA polymerase II (RNAP II) pausing. Results: Paused RNAP II recruits a transcription termination factor and a transcriptional corepressor complex to the HIV promoter. Conclusion: PausedRNAPII couples premature transcription termination and chromatin remodeling to maintain HIV latency. Significance: Paused RNAP II may be targeted to purge latent HIV infection.
AB - Background: Multiple mechanisms contribute to HIV latency, including NELF-mediated RNA polymerase II (RNAP II) pausing. Results: Paused RNAP II recruits a transcription termination factor and a transcriptional corepressor complex to the HIV promoter. Conclusion: PausedRNAPII couples premature transcription termination and chromatin remodeling to maintain HIV latency. Significance: Paused RNAP II may be targeted to purge latent HIV infection.
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U2 - 10.1074/jbc.M113.496489
DO - 10.1074/jbc.M113.496489
M3 - Article
C2 - 23884411
AN - SCOPUS:84883708671
SN - 0021-9258
VL - 288
SP - 25995
EP - 26003
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 36
ER -