TY - JOUR
T1 - Neoplastic Meningitis and Paraneoplastic Syndromes
AU - Kanekar, Sangam
AU - Zacharia, Thomas
AU - Agarwal, Amit
PY - 2021/5
Y1 - 2021/5
N2 - Neoplastic meningitis (NM) and paraneoplastic syndromes (PNSs) are a rare group of disorders present in patients with cancer. Clinical diagnosis of these conditions is challenging, and imaging and laboratory analysis play a significant role in diagnosing. Diagnosis of NM largely depends on documenting circulating tumor cells in the cerebrospinal fluid (CSF) and/or leptomeningeal and nodular enhancement on contrast-enhanced MR imaging of the brain or axial spine. PNSs encompass a variety of symptoms or syndromes. Paraneoplastic neuronal disorder diagnosis requires a multidimensional approach, high clinical suspicion, CSF and serum examination, and imaging. Neuroimaging is an integral part in the evaluation.
AB - Neoplastic meningitis (NM) and paraneoplastic syndromes (PNSs) are a rare group of disorders present in patients with cancer. Clinical diagnosis of these conditions is challenging, and imaging and laboratory analysis play a significant role in diagnosing. Diagnosis of NM largely depends on documenting circulating tumor cells in the cerebrospinal fluid (CSF) and/or leptomeningeal and nodular enhancement on contrast-enhanced MR imaging of the brain or axial spine. PNSs encompass a variety of symptoms or syndromes. Paraneoplastic neuronal disorder diagnosis requires a multidimensional approach, high clinical suspicion, CSF and serum examination, and imaging. Neuroimaging is an integral part in the evaluation.
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U2 - 10.1016/j.rcl.2021.01.007
DO - 10.1016/j.rcl.2021.01.007
M3 - Review article
C2 - 33926686
AN - SCOPUS:85105213615
SN - 0033-8389
VL - 59
SP - 409
EP - 423
JO - Radiologic Clinics of North America
JF - Radiologic Clinics of North America
IS - 3
ER -
