Nested genes and increasing organizational complexity of metazoan genomes

Raquel Assis, Alexey S. Kondrashov, Eugene V. Koonin, Fyodor A. Kondrashov

Research output: Contribution to journalShort surveypeer-review

35 Scopus citations


The most common form of protein-coding gene overlap in eukaryotes is a simple nested structure, whereby one gene is embedded in an intron of another. Analysis of nested protein-coding genes in vertebrates, fruit flies and nematodes revealed substantially higher rates of evolutionary gains than losses. The accumulation of nested gene structures could not be attributed to any obvious functional relationships between the genes involved and represents an increase of the organizational complexity of animal genomes via a neutral process.

Original languageEnglish (US)
Pages (from-to)475-478
Number of pages4
JournalTrends in Genetics
Issue number10
StatePublished - Oct 2008

All Science Journal Classification (ASJC) codes

  • Genetics


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