Nested genes and increasing organizational complexity of metazoan genomes

Raquel Assis; Alexey S. Kondrashov; Eugene V. Koonin; Fyodor A. Kondrashov

doi:10.1016/j.tig.2008.08.003

Nested genes and increasing organizational complexity of metazoan genomes

Raquel Assis
, Alexey S. Kondrashov
, Eugene V. Koonin
, Fyodor A. Kondrashov

Biology

Research output: Contribution to journal › Short survey › peer-review

42 Scopus citations

Abstract

The most common form of protein-coding gene overlap in eukaryotes is a simple nested structure, whereby one gene is embedded in an intron of another. Analysis of nested protein-coding genes in vertebrates, fruit flies and nematodes revealed substantially higher rates of evolutionary gains than losses. The accumulation of nested gene structures could not be attributed to any obvious functional relationships between the genes involved and represents an increase of the organizational complexity of animal genomes via a neutral process.

Original language	English (US)
Pages (from-to)	475-478
Number of pages	4
Journal	Trends in Genetics
Volume	24
Issue number	10
DOIs	https://doi.org/10.1016/j.tig.2008.08.003
State	Published - Oct 2008

All Science Journal Classification (ASJC) codes

Genetics

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10.1016/j.tig.2008.08.003

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abstract = "The most common form of protein-coding gene overlap in eukaryotes is a simple nested structure, whereby one gene is embedded in an intron of another. Analysis of nested protein-coding genes in vertebrates, fruit flies and nematodes revealed substantially higher rates of evolutionary gains than losses. The accumulation of nested gene structures could not be attributed to any obvious functional relationships between the genes involved and represents an increase of the organizational complexity of animal genomes via a neutral process.",

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AU - Koonin, Eugene V.

AU - Kondrashov, Fyodor A.

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AB - The most common form of protein-coding gene overlap in eukaryotes is a simple nested structure, whereby one gene is embedded in an intron of another. Analysis of nested protein-coding genes in vertebrates, fruit flies and nematodes revealed substantially higher rates of evolutionary gains than losses. The accumulation of nested gene structures could not be attributed to any obvious functional relationships between the genes involved and represents an increase of the organizational complexity of animal genomes via a neutral process.

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DO - 10.1016/j.tig.2008.08.003

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Nested genes and increasing organizational complexity of metazoan genomes

Abstract

All Science Journal Classification (ASJC) codes

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