TY - JOUR
T1 - Neural Predictors of Improvement With Cognitive Behavioral Therapy for Adolescents With Depression
T2 - An Examination of Reward Responsiveness and Emotion Regulation
AU - Dickey, Lindsay
AU - Pegg, Samantha
AU - Cárdenas, Emilia F.
AU - Green, Haley
AU - Dao, Anh
AU - Waxmonsky, James
AU - Pérez-Edgar, Koraly
AU - Kujawa, Autumn
N1 - Funding Information:
We would like to thank Sierra Brown, Ashley Carroll, Lauren Henry, Bridget Nestor, Elizabeth Nick, Kemar Prussien, Rachel Siciliano, Jennifer Stewart, and Allison Vreeland for leading and co-leading CBT groups. We would also like to thank Judy Garber and Bruce Compas for their guidance and mentorship when the lab and project moved to Vanderbilt University.
Funding Information:
This work was supported by a Klingenstein Third Generation Foundation Fellowship and the Brain and Behavior Research Foundation Katherine Deschner Family Young Investigator Grant awarded to A.K. Research was also supported in part by UL1 TR000445 from NCATS/NIH. SP was supported by NIH/NIMH T32-MH18921and F31MH127817-01 during this work. LD was supported by a NIH/NIMH F31MH127863-01A1 during this work.
Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/8
Y1 - 2023/8
N2 - Earlier depression onsets are associated with more debilitating courses and poorer life quality, highlighting the importance of effective early intervention. Many youths fail to improve with evidence-based treatments for depression, likely due in part to heterogeneity within the disorder. Multi-method assessment of individual differences in positive and negative emotion processing could improve predictions of treatment outcomes. The current study examined self-report and neurophysiological measures of reward responsiveness and emotion regulation as predictors of response to cognitive-behavioral therapy (CBT). Adolescents (14–18 years) with depression (N = 70) completed monetary reward and emotion regulation tasks while electroencephalogram (EEG) was recorded, and self-report measures of reward responsiveness, emotion regulation, and depressive symptoms at intake. Adolescents then completed a 16-session group CBT program, with depressive symptoms and clinician-rated improvement assessed across treatment. Lower reward positivity amplitudes, reflecting reduced neural reward responsiveness, predicted lower depressive symptoms with treatment. Larger late positive potential residuals during reappraisal, potentially reflecting difficulty with emotion regulation, predicted greater clinician-rated improvement. Self-report measures were not significant predictors. Results support the clinical utility of EEG measures, with impairments in positive and negative emotion processing predicting greater change with interventions that target these processes.
AB - Earlier depression onsets are associated with more debilitating courses and poorer life quality, highlighting the importance of effective early intervention. Many youths fail to improve with evidence-based treatments for depression, likely due in part to heterogeneity within the disorder. Multi-method assessment of individual differences in positive and negative emotion processing could improve predictions of treatment outcomes. The current study examined self-report and neurophysiological measures of reward responsiveness and emotion regulation as predictors of response to cognitive-behavioral therapy (CBT). Adolescents (14–18 years) with depression (N = 70) completed monetary reward and emotion regulation tasks while electroencephalogram (EEG) was recorded, and self-report measures of reward responsiveness, emotion regulation, and depressive symptoms at intake. Adolescents then completed a 16-session group CBT program, with depressive symptoms and clinician-rated improvement assessed across treatment. Lower reward positivity amplitudes, reflecting reduced neural reward responsiveness, predicted lower depressive symptoms with treatment. Larger late positive potential residuals during reappraisal, potentially reflecting difficulty with emotion regulation, predicted greater clinician-rated improvement. Self-report measures were not significant predictors. Results support the clinical utility of EEG measures, with impairments in positive and negative emotion processing predicting greater change with interventions that target these processes.
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U2 - 10.1007/s10802-023-01054-z
DO - 10.1007/s10802-023-01054-z
M3 - Article
C2 - 37084164
AN - SCOPUS:85153227954
SN - 2730-7166
VL - 51
SP - 1069
EP - 1082
JO - Research on Child and Adolescent Psychopathology
JF - Research on Child and Adolescent Psychopathology
IS - 8
ER -