TY - JOUR
T1 - Neural responses to exercise in humans
T2 - Implications for congestive heart failure
AU - Sinoway, Lawrence
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1996
Y1 - 1996
N2 - 1. During static handgrip exercise, muscle metaboreceptors are stimulated, evoking the 'exercise presser reflex'. As part of this reflex, sympathetic discharge to skeletal muscle is increased. The muscle 'metaboreceptors' are thought to be free nerve endings of unmyelinated group IV nerve fibres. These receptors are stimulated by a number of metabolites, including tactic acid, H+, diprotonated phosphate, adenosine and the biproducts of prostaglandin synthesis. 2. During chronic, repetitive activity, muscle metabolite-sensitive afferents may be desensitized. We speculate that metaboreceptor desensitization also occurs in congestive heart failure (HF). Despite this desensitization, sympathoexcitatory responses to forearm exercise are preserved. This suggests that some other neural system aside from muscle metaboreceptors must be activated to a greater degree in HF. We speculate that in HF the activity of muscle mechanoreceptors is increased. Furthermore, we believe that limb congestion can increase the discharge of muscle mechanoreceptors, thereby evoking non-metaboreceptor-mediated increases in sympathetic discharge. Future studies in our laboratory will examine the role limb congestion and decongestion play in evoking muscle mechanoreceptor-mediated sympathoexcitatory responses.
AB - 1. During static handgrip exercise, muscle metaboreceptors are stimulated, evoking the 'exercise presser reflex'. As part of this reflex, sympathetic discharge to skeletal muscle is increased. The muscle 'metaboreceptors' are thought to be free nerve endings of unmyelinated group IV nerve fibres. These receptors are stimulated by a number of metabolites, including tactic acid, H+, diprotonated phosphate, adenosine and the biproducts of prostaglandin synthesis. 2. During chronic, repetitive activity, muscle metabolite-sensitive afferents may be desensitized. We speculate that metaboreceptor desensitization also occurs in congestive heart failure (HF). Despite this desensitization, sympathoexcitatory responses to forearm exercise are preserved. This suggests that some other neural system aside from muscle metaboreceptors must be activated to a greater degree in HF. We speculate that in HF the activity of muscle mechanoreceptors is increased. Furthermore, we believe that limb congestion can increase the discharge of muscle mechanoreceptors, thereby evoking non-metaboreceptor-mediated increases in sympathetic discharge. Future studies in our laboratory will examine the role limb congestion and decongestion play in evoking muscle mechanoreceptor-mediated sympathoexcitatory responses.
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U2 - 10.1111/j.1440-1681.1996.tb01761.x
DO - 10.1111/j.1440-1681.1996.tb01761.x
M3 - Article
C2 - 8886493
AN - SCOPUS:0029851876
SN - 0305-1870
VL - 23
SP - 693
EP - 699
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
IS - 8
ER -