Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold

Navjot Kaur, Wenqi Han, Zhuo Li, M. Pilar Madrigal, Sungbo Shim, Sirisha Pochareddy, Forrest O. Gulden, Mingfeng Li, Xuming Xu, Xiaojun Xing, Yutaka Takeo, Zhen Li, Kangrong Lu, Yuka Imamura Kawasawa, Begoña Ballester-Lurbe, Juan Antonio Moreno-Bravo, Alain Chédotal, José Terrado, Ignacio Pérez-Roger, Anthony J. KoleskeNenad Sestan

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Kaur et al. show that the radial glial scaffold of neural stem cells from medial ganglionic eminence directs corticospinal and other axons through a previously unknown choice point at the striatopallidal junction in an RND3/ARHGAP35-dependent manner. Within corticospinal neurons, FEZF2-dependent Rnd3 expression regulates dendritic spinogenesis, axon elongation, and pontine midline crossing.

Original languageEnglish (US)
Pages (from-to)1197-1211.e9
JournalNeuron
Volume107
Issue number6
DOIs
StatePublished - Sep 23 2020

All Science Journal Classification (ASJC) codes

  • General Neuroscience

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