Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold

Navjot Kaur; Wenqi Han; Zhuo Li; M. Pilar Madrigal; Sungbo Shim; Sirisha Pochareddy; Forrest O. Gulden; Mingfeng Li; Xuming Xu; Xiaojun Xing; Yutaka Takeo; Zhen Li; Kangrong Lu; Yuka Imamura Kawasawa; Begoña Ballester-Lurbe; Juan Antonio Moreno-Bravo; Alain Chédotal; José Terrado; Ignacio Pérez-Roger; Anthony J. Koleske; Nenad Sestan

doi:10.1016/j.neuron.2020.06.035

Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold

Navjot Kaur, Wenqi Han, Zhuo Li, M. Pilar Madrigal, Sungbo Shim, Sirisha Pochareddy, Forrest O. Gulden, Mingfeng Li, Xuming Xu, Xiaojun Xing, Yutaka Takeo, Zhen Li, Kangrong Lu, Yuka Imamura Kawasawa, Begoña Ballester-Lurbe, Juan Antonio Moreno-Bravo, Alain Chédotal, José Terrado, Ignacio Pérez-Roger, Anthony J. KoleskeNenad Sestan

Department of Neuroscience and Experimental Therapeutics

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Kaur et al. show that the radial glial scaffold of neural stem cells from medial ganglionic eminence directs corticospinal and other axons through a previously unknown choice point at the striatopallidal junction in an RND3/ARHGAP35-dependent manner. Within corticospinal neurons, FEZF2-dependent Rnd3 expression regulates dendritic spinogenesis, axon elongation, and pontine midline crossing.

Original language	English (US)
Pages (from-to)	1197-1211.e9
Journal	Neuron
Volume	107
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2020.06.035
State	Published - Sep 23 2020

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/j.neuron.2020.06.035

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Kaur, N., Han, W., Li, Z., Madrigal, M. P., Shim, S., Pochareddy, S., Gulden, F. O., Li, M., Xu, X., Xing, X., Takeo, Y., Li, Z., Lu, K., Imamura Kawasawa, Y., Ballester-Lurbe, B., Moreno-Bravo, J. A., Chédotal, A., Terrado, J., Pérez-Roger, I., ... Sestan, N. (2020). Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold. Neuron, 107(6), 1197-1211.e9. https://doi.org/10.1016/j.neuron.2020.06.035

@article{c101727e03c846bbbcb43bfa2cd1bd86,

title = "Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold",

abstract = "Kaur et al. show that the radial glial scaffold of neural stem cells from medial ganglionic eminence directs corticospinal and other axons through a previously unknown choice point at the striatopallidal junction in an RND3/ARHGAP35-dependent manner. Within corticospinal neurons, FEZF2-dependent Rnd3 expression regulates dendritic spinogenesis, axon elongation, and pontine midline crossing.",

author = "Navjot Kaur and Wenqi Han and Zhuo Li and Madrigal, {M. Pilar} and Sungbo Shim and Sirisha Pochareddy and Gulden, {Forrest O.} and Mingfeng Li and Xuming Xu and Xiaojun Xing and Yutaka Takeo and Zhen Li and Kangrong Lu and {Imamura Kawasawa}, Yuka and Bego{\~n}a Ballester-Lurbe and Moreno-Bravo, {Juan Antonio} and Alain Ch{\'e}dotal and Jos{\'e} Terrado and Ignacio P{\'e}rez-Roger and Koleske, {Anthony J.} and Nenad Sestan",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = sep,

day = "23",

doi = "10.1016/j.neuron.2020.06.035",

language = "English (US)",

volume = "107",

pages = "1197--1211.e9",

journal = "Neuron",

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Kaur, N, Han, W, Li, Z, Madrigal, MP, Shim, S, Pochareddy, S, Gulden, FO, Li, M, Xu, X, Xing, X, Takeo, Y, Li, Z, Lu, K, Imamura Kawasawa, Y, Ballester-Lurbe, B, Moreno-Bravo, JA, Chédotal, A, Terrado, J, Pérez-Roger, I, Koleske, AJ & Sestan, N 2020, 'Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold', Neuron, vol. 107, no. 6, pp. 1197-1211.e9. https://doi.org/10.1016/j.neuron.2020.06.035

TY - JOUR

T1 - Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold

AU - Kaur, Navjot

AU - Han, Wenqi

AU - Li, Zhuo

AU - Madrigal, M. Pilar

AU - Shim, Sungbo

AU - Pochareddy, Sirisha

AU - Gulden, Forrest O.

AU - Li, Mingfeng

AU - Xu, Xuming

AU - Xing, Xiaojun

AU - Takeo, Yutaka

AU - Li, Zhen

AU - Lu, Kangrong

AU - Imamura Kawasawa, Yuka

AU - Ballester-Lurbe, Begoña

AU - Moreno-Bravo, Juan Antonio

AU - Chédotal, Alain

AU - Terrado, José

AU - Pérez-Roger, Ignacio

AU - Koleske, Anthony J.

AU - Sestan, Nenad

PY - 2020/9/23

Y1 - 2020/9/23

N2 - Kaur et al. show that the radial glial scaffold of neural stem cells from medial ganglionic eminence directs corticospinal and other axons through a previously unknown choice point at the striatopallidal junction in an RND3/ARHGAP35-dependent manner. Within corticospinal neurons, FEZF2-dependent Rnd3 expression regulates dendritic spinogenesis, axon elongation, and pontine midline crossing.

AB - Kaur et al. show that the radial glial scaffold of neural stem cells from medial ganglionic eminence directs corticospinal and other axons through a previously unknown choice point at the striatopallidal junction in an RND3/ARHGAP35-dependent manner. Within corticospinal neurons, FEZF2-dependent Rnd3 expression regulates dendritic spinogenesis, axon elongation, and pontine midline crossing.

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JO - Neuron

JF - Neuron

IS - 6

ER -

Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold

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