Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold

Navjot Kaur; Wenqi Han; Zhuo Li; M. Pilar Madrigal; Sungbo Shim; Sirisha Pochareddy; Forrest O. Gulden; Mingfeng Li; Xuming Xu; Xiaojun Xing; Yutaka Takeo; Zhen Li; Kangrong Lu; Yuka Imamura Kawasawa; Begoña Ballester-Lurbe; Juan Antonio Moreno-Bravo; Alain Chédotal; José Terrado; Ignacio Pérez-Roger; Anthony J. Koleske; Nenad Sestan

doi:10.1016/j.neuron.2020.06.035

Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold

Navjot Kaur
, Wenqi Han
, Zhuo Li
, M. Pilar Madrigal
, Sungbo Shim
, Sirisha Pochareddy
, Forrest O. Gulden
, Mingfeng Li
, Xuming Xu
, Xiaojun Xing
, Yutaka Takeo
, Zhen Li
, Kangrong Lu
, Yuka Imamura Kawasawa
, Begoña Ballester-Lurbe
, Juan Antonio Moreno-Bravo
, Alain Chédotal
, José Terrado
, Ignacio Pérez-Roger
, Anthony J. Koleske

Nenad Sestan

Department of Neuroscience and Experimental Therapeutics

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Kaur et al. show that the radial glial scaffold of neural stem cells from medial ganglionic eminence directs corticospinal and other axons through a previously unknown choice point at the striatopallidal junction in an RND3/ARHGAP35-dependent manner. Within corticospinal neurons, FEZF2-dependent Rnd3 expression regulates dendritic spinogenesis, axon elongation, and pontine midline crossing.

Original language	English (US)
Pages (from-to)	1197-1211.e9
Journal	Neuron
Volume	107
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2020.06.035
State	Published - Sep 23 2020

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/j.neuron.2020.06.035

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Kaur, N., Han, W., Li, Z., Madrigal, M. P., Shim, S., Pochareddy, S., Gulden, F. O., Li, M., Xu, X., Xing, X., Takeo, Y., Li, Z., Lu, K., Imamura Kawasawa, Y., Ballester-Lurbe, B., Moreno-Bravo, J. A., Chédotal, A., Terrado, J., Pérez-Roger, I., ... Sestan, N. (2020). Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold. Neuron, 107(6), 1197-1211.e9. https://doi.org/10.1016/j.neuron.2020.06.035

@article{c101727e03c846bbbcb43bfa2cd1bd86,

title = "Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold",

abstract = "Kaur et al. show that the radial glial scaffold of neural stem cells from medial ganglionic eminence directs corticospinal and other axons through a previously unknown choice point at the striatopallidal junction in an RND3/ARHGAP35-dependent manner. Within corticospinal neurons, FEZF2-dependent Rnd3 expression regulates dendritic spinogenesis, axon elongation, and pontine midline crossing.",

author = "Navjot Kaur and Wenqi Han and Zhuo Li and Madrigal, \{M. Pilar\} and Sungbo Shim and Sirisha Pochareddy and Gulden, \{Forrest O.\} and Mingfeng Li and Xuming Xu and Xiaojun Xing and Yutaka Takeo and Zhen Li and Kangrong Lu and \{Imamura Kawasawa\}, Yuka and Bego{\~n}a Ballester-Lurbe and Moreno-Bravo, \{Juan Antonio\} and Alain Ch{\'e}dotal and Jos{\'e} Terrado and Ignacio P{\'e}rez-Roger and Koleske, \{Anthony J.\} and Nenad Sestan",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = sep,

day = "23",

doi = "10.1016/j.neuron.2020.06.035",

language = "English (US)",

volume = "107",

pages = "1197--1211.e9",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

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Kaur, N, Han, W, Li, Z, Madrigal, MP, Shim, S, Pochareddy, S, Gulden, FO, Li, M, Xu, X, Xing, X, Takeo, Y, Li, Z, Lu, K, Imamura Kawasawa, Y, Ballester-Lurbe, B, Moreno-Bravo, JA, Chédotal, A, Terrado, J, Pérez-Roger, I, Koleske, AJ & Sestan, N 2020, 'Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold', Neuron, vol. 107, no. 6, pp. 1197-1211.e9. https://doi.org/10.1016/j.neuron.2020.06.035

TY - JOUR

T1 - Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold

AU - Kaur, Navjot

AU - Han, Wenqi

AU - Li, Zhuo

AU - Madrigal, M. Pilar

AU - Shim, Sungbo

AU - Pochareddy, Sirisha

AU - Gulden, Forrest O.

AU - Li, Mingfeng

AU - Xu, Xuming

AU - Xing, Xiaojun

AU - Takeo, Yutaka

AU - Li, Zhen

AU - Lu, Kangrong

AU - Imamura Kawasawa, Yuka

AU - Ballester-Lurbe, Begoña

AU - Moreno-Bravo, Juan Antonio

AU - Chédotal, Alain

AU - Terrado, José

AU - Pérez-Roger, Ignacio

AU - Koleske, Anthony J.

AU - Sestan, Nenad

PY - 2020/9/23

Y1 - 2020/9/23

N2 - Kaur et al. show that the radial glial scaffold of neural stem cells from medial ganglionic eminence directs corticospinal and other axons through a previously unknown choice point at the striatopallidal junction in an RND3/ARHGAP35-dependent manner. Within corticospinal neurons, FEZF2-dependent Rnd3 expression regulates dendritic spinogenesis, axon elongation, and pontine midline crossing.

AB - Kaur et al. show that the radial glial scaffold of neural stem cells from medial ganglionic eminence directs corticospinal and other axons through a previously unknown choice point at the striatopallidal junction in an RND3/ARHGAP35-dependent manner. Within corticospinal neurons, FEZF2-dependent Rnd3 expression regulates dendritic spinogenesis, axon elongation, and pontine midline crossing.

UR - https://www.scopus.com/pages/publications/85089288235

UR - https://www.scopus.com/pages/publications/85089288235#tab=citedBy

U2 - 10.1016/j.neuron.2020.06.035

DO - 10.1016/j.neuron.2020.06.035

M3 - Article

C2 - 32707082

AN - SCOPUS:85089288235

SN - 0896-6273

VL - 107

SP - 1197-1211.e9

JO - Neuron

JF - Neuron

IS - 6

ER -

Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold

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