Neuroanatomical Correlates of Heterotypic Comorbidity in Externalizing Male Adolescents

Colin L. Sauder, Theodore P. Beauchaine, Lisa M. Gatzke-Kopp, Katherine E. Shannon, Elizabeth Aylward

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Children and adolescents with externalizing behavior disorders including attentiondeficit/hyperactivity disorder (ADHD) and conduct disorder (CD) often present with symptoms of comorbid internalizing psychopathology. However, few studies have examined central nervous system correlates of such comorbidity. We evaluated interactions between externalizing and internalizing symptoms in predicting mesolimbic, septo-hippocampal, and anterior cingulate volumes among 12- to 16-year-old boys with either ADHD, ADHD and CD, or no psychiatric condition (n = 35). These regions were chosen given established links to trait impulsivity, trait anxiety, and behavior regulation, respectively. Collapsed across groups, Externalizing × Internalizing symptom interactions accounted for individual differences in gray matter densities in each region. Externalizing youth with comorbid internalizing symptoms showed smaller reductions in gray matter than individuals with externalizing psychopathology alone. These results suggest that internalizing symptoms are associated with less severe structural compromises in brain regions subserving motivation and behavior regulation among externalizing boys.

Original languageEnglish (US)
Pages (from-to)346-352
Number of pages7
JournalJournal of Clinical Child and Adolescent Psychology
Issue number3
StatePublished - May 2012

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology
  • Clinical Psychology


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