TY - JOUR
T1 - Neuroanatomical Correlates of Heterotypic Comorbidity in Externalizing Male Adolescents
AU - Sauder, Colin L.
AU - Beauchaine, Theodore P.
AU - Gatzke-Kopp, Lisa M.
AU - Shannon, Katherine E.
AU - Aylward, Elizabeth
N1 - Funding Information:
Work on this article was supported by grant 3289 from the University of Washington Royalty Research Fund.
PY - 2012/5
Y1 - 2012/5
N2 - Children and adolescents with externalizing behavior disorders including attentiondeficit/hyperactivity disorder (ADHD) and conduct disorder (CD) often present with symptoms of comorbid internalizing psychopathology. However, few studies have examined central nervous system correlates of such comorbidity. We evaluated interactions between externalizing and internalizing symptoms in predicting mesolimbic, septo-hippocampal, and anterior cingulate volumes among 12- to 16-year-old boys with either ADHD, ADHD and CD, or no psychiatric condition (n = 35). These regions were chosen given established links to trait impulsivity, trait anxiety, and behavior regulation, respectively. Collapsed across groups, Externalizing × Internalizing symptom interactions accounted for individual differences in gray matter densities in each region. Externalizing youth with comorbid internalizing symptoms showed smaller reductions in gray matter than individuals with externalizing psychopathology alone. These results suggest that internalizing symptoms are associated with less severe structural compromises in brain regions subserving motivation and behavior regulation among externalizing boys.
AB - Children and adolescents with externalizing behavior disorders including attentiondeficit/hyperactivity disorder (ADHD) and conduct disorder (CD) often present with symptoms of comorbid internalizing psychopathology. However, few studies have examined central nervous system correlates of such comorbidity. We evaluated interactions between externalizing and internalizing symptoms in predicting mesolimbic, septo-hippocampal, and anterior cingulate volumes among 12- to 16-year-old boys with either ADHD, ADHD and CD, or no psychiatric condition (n = 35). These regions were chosen given established links to trait impulsivity, trait anxiety, and behavior regulation, respectively. Collapsed across groups, Externalizing × Internalizing symptom interactions accounted for individual differences in gray matter densities in each region. Externalizing youth with comorbid internalizing symptoms showed smaller reductions in gray matter than individuals with externalizing psychopathology alone. These results suggest that internalizing symptoms are associated with less severe structural compromises in brain regions subserving motivation and behavior regulation among externalizing boys.
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U2 - 10.1080/15374416.2012.658612
DO - 10.1080/15374416.2012.658612
M3 - Article
C2 - 22432457
AN - SCOPUS:84861304172
SN - 1537-4416
VL - 41
SP - 346
EP - 352
JO - Journal of Clinical Child and Adolescent Psychology
JF - Journal of Clinical Child and Adolescent Psychology
IS - 3
ER -