@article{98a2ca5092d94e8d95df554cb0705883,
title = "NeuroD1 overexpression in spinal neurons accelerates axonal regeneration after sciatic nerve injury",
abstract = "Neurogenic differentiation 1 (NeuroD1) is mainlyexpressed in developing neurons where it plays critical roles in neuronal maturation and neurite elongation. The potential role and mechanism of NeuroD1 in adult axonal regeneration is not clear. The present study used synapsin (SYN) Cre and AAV9-Flex vectors to conditionally overexpress NeuroD1 in adult spinal neurons and found that NeuroD1 overexpression significantly accelerated axonal regeneration and functional recovery after sciatic nerve injury. Further in vitro and in vivo experiments suggested that the mechanism of NeuroD1 promotion on axonal regeneration was related to its regulation of the expression of neurotrophin BDNF and its receptor TrkB as well as a microtubule severing protein spastin.",
author = "Muhua Lai and Mengjie Pan and Longjiao Ge and Jingmin Liu and Junyao Deng and Xianghai Wang and Lixia Li and Jinkun Wen and Dandan Tan and Haowen Zhang and Xiaofang Hu and Lanya Fu and Yizhou Xu and Zhenlin Li and Xiaozhong Qiu and Gong Chen and Jiasong Guo",
note = "Funding Information: This work was supported by the National Natural Science Foundation of China (81870982, 81571182 & 81371354); National Key Basic Research Program of China (2014CB542202); the Program for Changjiang Scholars and Innovative Research Team in University (IRT-16R37); Research Grant of Guangdong Province Key Laboratory of Psychiatric Disorders (N201904); Key Research & Development Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory (2018GZR110104008) and Natural Science Foundation of Guangdong Province (2017A030312009). Funding Information: This work was supported by the National Natural Science Foundation of China ( 81870982 , 81571182 & 81371354 ); National Key Basic Research Program of China ( 2014CB542202 ); the Program for Changjiang Scholars and Innovative Research Team in University ( IRT-16R37 ); Research Grant of Guangdong Province Key Laboratory of Psychiatric Disorders ( N201904 ); Key Research & Development Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory ( 2018GZR110104008 ) and Natural Science Foundation of Guangdong Province ( 2017A030312009 ). Publisher Copyright: {\textcopyright} 2020",
year = "2020",
month = may,
doi = "10.1016/j.expneurol.2020.113215",
language = "English (US)",
volume = "327",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
}