Neurogenic syndromes and their pathogenetic therapy

M. L. Kukushkin, V. K. Reshetnyak, M. Vorobeichik Ya.

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Analgesic effects of morphine, clofelin, sirdalud, propranolol, and verapamil were studied in animals with the neurogenic painful syndrome induced by cutting the sciatic nerve and in patients with phantom painful syndrome after limb amputation. In animals with cut sciatic nerve morphine not only failed to prevent neurogenic pain, but was conducive to its increase. And, on the contrary, nontraditional analgesics clofelin, sirdalud, propranolol, and verapamil showed a high therapeutic efficacy both in experiments and in clinical trials. The results are discussed from the viewpoint of pathogenetic mechanisms of development of neurogenic painful syndromes.

Original languageEnglish (US)
Pages (from-to)36-41
Number of pages6
JournalRussian Journal of Anesthesiology and Reanimatology
Issue number4
StatePublished - 1994

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine


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