Neuroleptic Malignant Syndrome: A Case Aimed at Raising Clinical Awareness

Jad Al Danaf, John Madara, Caitlin Dietsche

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A 60-year-old man with a history of bipolar disorder on risperidone, bupropion, and escitalopram was admitted for community acquired streptococcal pneumonia. Four days later, he developed persistent hyperthermia, dysautonomia, rigidity, hyporeflexia, and marked elevation of serum creatine phosphokinase. He was diagnosed with neuroleptic malignant syndrome (NMS) and improved with dantrolene, bromocriptine, and supportive therapy. This case emphasizes the importance of considering a broad differential diagnosis for fever in the ICU, carefully reviewing the medication list for all patients, and considering NMS in patients with fever and rigidity.

Original languageEnglish (US)
Article number769576
JournalCase Reports in Medicine
StatePublished - 2015

All Science Journal Classification (ASJC) codes

  • General Medicine


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