Neuroleukemiosis: Case report of leukemic nerve infiltration in acute lymphoblastic leukemia

Dawit G. Aregawi; Jonathan H. Sherman; Michael G. Douvas; Ted M. Burns; David Schiff

doi:10.1002/mus.21089

Neuroleukemiosis: Case report of leukemic nerve infiltration in acute lymphoblastic leukemia

Dawit G. Aregawi, Jonathan H. Sherman, Michael G. Douvas, Ted M. Burns, David Schiff

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31 Scopus citations

Abstract

We describe a patient in remission from acute lymphoblastic leukemia who developed a painless common peroneal neuropathy. Magnetic resonance imaging (MRI) revealed nerve thickening and enhancement, while a positron emission tomography (PET) scan demonstrated increased fluorodeoxyglucose uptake in a large segment of the neurovascular bundle, suggesting peripheral nerve infiltration. Both findings resolved following treatment with chemotherapy that crossed the blood-nerve barrier. In selected patients presenting with peripheral neuropathy, MRI and PET scan can be helpful in the diagnosis of peripheral nerve infiltration.

Original language	English (US)
Pages (from-to)	1196-1200
Number of pages	5
Journal	Muscle and Nerve
Volume	38
Issue number	3
DOIs	https://doi.org/10.1002/mus.21089
State	Published - Sep 2008

All Science Journal Classification (ASJC) codes

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/mus.21089

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abstract = "We describe a patient in remission from acute lymphoblastic leukemia who developed a painless common peroneal neuropathy. Magnetic resonance imaging (MRI) revealed nerve thickening and enhancement, while a positron emission tomography (PET) scan demonstrated increased fluorodeoxyglucose uptake in a large segment of the neurovascular bundle, suggesting peripheral nerve infiltration. Both findings resolved following treatment with chemotherapy that crossed the blood-nerve barrier. In selected patients presenting with peripheral neuropathy, MRI and PET scan can be helpful in the diagnosis of peripheral nerve infiltration.",

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AU - Douvas, Michael G.

AU - Burns, Ted M.

AU - Schiff, David

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AB - We describe a patient in remission from acute lymphoblastic leukemia who developed a painless common peroneal neuropathy. Magnetic resonance imaging (MRI) revealed nerve thickening and enhancement, while a positron emission tomography (PET) scan demonstrated increased fluorodeoxyglucose uptake in a large segment of the neurovascular bundle, suggesting peripheral nerve infiltration. Both findings resolved following treatment with chemotherapy that crossed the blood-nerve barrier. In selected patients presenting with peripheral neuropathy, MRI and PET scan can be helpful in the diagnosis of peripheral nerve infiltration.

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Neuroleukemiosis: Case report of leukemic nerve infiltration in acute lymphoblastic leukemia

Abstract

All Science Journal Classification (ASJC) codes

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