Neuronal cell deficits following maternal exposure to methadone in rats

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Rat offspring were maternally subjected to methadone hydrochloride during gestation or lactation. At 21 days of age, the area of the pyramis (cerebellar lobule VIII) in prenatally and postnatally exposed groups was reduced 45% and 36%, respectively, from control levels, and the total number of internal granule neurons/section was reduced 49% and 46%, respectively; the number of granule neurons/mm2 in both groups was 75% of control values. Based on histological evaluation the timetable of cerebellar morphogenesis was unaltered in rats prenatally exposed to methadone, suggesting a permanent neuronal deficit, but cerebellar development was markedly delayed in animals subjected postnatally.

Original languageEnglish (US)
Pages (from-to)1214-1216
Number of pages3
Issue number10
StatePublished - Oct 1 1982

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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