Neuropeptide Y infusion decreases plasma renin activity in postmyocardial infarction rats

We wished to determine if chronic neuropeptide Y (NPY) infusion (1 ng/min for 1 week by Alzet minipump) could decrease plasma renin activity (PRA) and norepinephrine (NE) in a rat myocardial infarction (MI) model of moderate compensated congestive heart failure (CHF). CHF was produced by prior (6-8 weeks) ligation of the left coronary artery; control rats were sham-operated. Carotid arterial blood was drawn for PRA and NE in conscious unrestrained rats that had been instrumented 24 h earlier. MI rats had increased PRA as compared with sham-operated rats [8.73 ± 1.27 vs. 5.10 ± 0.91 ng angiotensin (AI) I/ml·h, mean ± SE]. During chronic NPY infusion, PRA was reduced to normal in the MI group (4.78 ± 0.91) but was not affected in the sham group (5.65 ± 0.51). Plasma NE was altered similarly, but the changes did not reach statistical significance. These data suggest that NPY has the capacity to restrain renin release in moderate compensated CHF.