TY - JOUR
T1 - Neuroprotective and antiangiogenic actions of PEDF in the eye
T2 - Molecular targets and therapeutic potential
AU - Barnstable, Colin J.
AU - Tombran-Tink, Joyce
N1 - Funding Information:
The work in the authors’ laboratories has been supported by grants from the NIH, Research to Prevent Blindness, Inc. and the David Woods Kemper Memorial Foundation.
PY - 2004/9
Y1 - 2004/9
N2 - Pigment epithelium-derived factor (PEDF) is a 50-kDa protein encoded by a single gene that shows strong conservation across phyla from fish to mammals. It is secreted by the retinal pigment epithelium (RPE) and a select number of other cell types in the eye, as well as by other tissues in the body. PEDF was originally defined by its ability to induce differentiation in retinoblastoma cells. It also promotes a non-proliferative, differentiated state in a number of other cell types. PEDF protects retinal neurons from light damage, oxidative stress and glutamate excitotoxicity. PEDF is also antiangiogenic and can inhibit the growth of blood vessels in the eye induced in a variety of ways. A balance in the levels of PEDF and the proangiogenic factor vascular endothelial growth factor-A is perturbed in a range of retinal neovascular diseases. Some of the pathways by which PEDF exerts its actions on cells have now been defined. Peptide fragments of PEDF carry biological activity and may be valuable therapeutic agents that readily penetrate the eye.
AB - Pigment epithelium-derived factor (PEDF) is a 50-kDa protein encoded by a single gene that shows strong conservation across phyla from fish to mammals. It is secreted by the retinal pigment epithelium (RPE) and a select number of other cell types in the eye, as well as by other tissues in the body. PEDF was originally defined by its ability to induce differentiation in retinoblastoma cells. It also promotes a non-proliferative, differentiated state in a number of other cell types. PEDF protects retinal neurons from light damage, oxidative stress and glutamate excitotoxicity. PEDF is also antiangiogenic and can inhibit the growth of blood vessels in the eye induced in a variety of ways. A balance in the levels of PEDF and the proangiogenic factor vascular endothelial growth factor-A is perturbed in a range of retinal neovascular diseases. Some of the pathways by which PEDF exerts its actions on cells have now been defined. Peptide fragments of PEDF carry biological activity and may be valuable therapeutic agents that readily penetrate the eye.
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U2 - 10.1016/j.preteyeres.2004.05.002
DO - 10.1016/j.preteyeres.2004.05.002
M3 - Review article
C2 - 15302351
AN - SCOPUS:4043074205
SN - 1350-9462
VL - 23
SP - 561
EP - 577
JO - Progress in Retinal and Eye Research
JF - Progress in Retinal and Eye Research
IS - 5
ER -