TY - JOUR
T1 - Neuropsychological functioning in girls with premature adrenarche
AU - Tissot, A.
AU - Dorn, L. D.
AU - Rotenstein, D.
AU - Rose, S. R.
AU - Sontag-Padilla, L. M.
AU - Jillard, C. L.
AU - Witchel, S. F.
AU - Berga, S. L.
AU - Loucks, T. L.
AU - Beers, S. R.
PY - 2012/1
Y1 - 2012/1
N2 - Contemporary research indicates that brain development occurs during childhood and into early adulthood, particularly in certain regions. A critical question is whether premature or atypical hormone exposures impact brain development (e.g., structure) or function (e.g., neuropsychological functioning). The current study enrolled 40 girls (aged 6-8 years) diagnosed with premature adrenarche (PA) and a comparison group of 36 girls with on-time maturation. It was hypothesized that girls with PA would demonstrate lower IQ and performance on several neuropsychological tasks. The potential for a sexually dimorphic neuropsychological profile in PA was also explored. No significant univariate or multivariate group differences emerged for any neuropsychological instrument. However, effect size confidence intervals contained medium-sized group differences at the subscale level. On-time girls performed better on verbal, working memory, and visuospatial tasks. Girls with PA showed improved attention, but not a sexually dimorphic profile. These results, though preliminary, suggest that premature maturation may influence neuropsychological functioning.
AB - Contemporary research indicates that brain development occurs during childhood and into early adulthood, particularly in certain regions. A critical question is whether premature or atypical hormone exposures impact brain development (e.g., structure) or function (e.g., neuropsychological functioning). The current study enrolled 40 girls (aged 6-8 years) diagnosed with premature adrenarche (PA) and a comparison group of 36 girls with on-time maturation. It was hypothesized that girls with PA would demonstrate lower IQ and performance on several neuropsychological tasks. The potential for a sexually dimorphic neuropsychological profile in PA was also explored. No significant univariate or multivariate group differences emerged for any neuropsychological instrument. However, effect size confidence intervals contained medium-sized group differences at the subscale level. On-time girls performed better on verbal, working memory, and visuospatial tasks. Girls with PA showed improved attention, but not a sexually dimorphic profile. These results, though preliminary, suggest that premature maturation may influence neuropsychological functioning.
UR - http://www.scopus.com/inward/record.url?scp=84855176494&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855176494&partnerID=8YFLogxK
U2 - 10.1017/S135561771100138X
DO - 10.1017/S135561771100138X
M3 - Article
C2 - 22114879
AN - SCOPUS:84855176494
SN - 1355-6177
VL - 18
SP - 151
EP - 156
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
IS - 1
ER -