Neuroscience-informed classification of prevention interventions in substance use disorders: An RDoC-based approach

Tara Rezapour, Parnian Rafei, Alex Baldacchino, Patricia J. Conrod, Geert Dom, Diana H. Fishbein, Atefeh Kazemi, Vincent Hendriks, Nicola Newton, Nathaniel R. Riggs, Lindsay M. Squeglia, Maree Teesson, Jasmin Vassileva, Antonio Verdejo-Garcia, Hamed Ekhtiari

Research output: Contribution to journalReview articlepeer-review


Neuroscience has contributed to uncover the mechanisms underpinning substance use disorders (SUD). The next frontier is to leverage these mechanisms as active targets to create more effective interventions for SUD treatment and prevention. Recent large-scale cohort studies from early childhood are generating multiple levels of neuroscience-based information with the potential to inform the development and refinement of future preventive strategies. However, there are still no available well-recognized frameworks to guide the integration of these multi-level datasets into prevention interventions. The Research Domain Criteria (RDoC) provides a neuroscience-based multi-system framework that is well suited to facilitate translation of neurobiological mechanisms into behavioral domains amenable to preventative interventions. We propose a novel RDoC-based framework for prevention science and adapted the framework for the existing preventive interventions. From a systematic review of randomized controlled trials using a person-centered drug/alcohol preventive approach for adolescents, we identified 22 unique preventive interventions. By teasing apart these 22 interventions into the RDoC domains, we proposed distinct neurocognitive trajectories which have been recognized as precursors or risk factors for SUDs, to be targeted, engaged and modified for effective addiction prevention.

Original languageEnglish (US)
Article number105578
JournalNeuroscience and Biobehavioral Reviews
StatePublished - Apr 2024

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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