TY - JOUR
T1 - Neurotrophins 3 and 4 enhance non-rapid eye movement sleep in rabbits
AU - Kushikata, Tetsuya
AU - Kubota, Takeshi
AU - Fang, Jidong
AU - Krueger, James M.
N1 - Funding Information:
This work was supported in part by grants from the National Institutes of Health (NS 25378 and NS 31453).
PY - 2003/8/7
Y1 - 2003/8/7
N2 - We determined if neurotrophins 3 and 4 (NT-3, NT-4) would promote sleep in rabbits. Two doses of NT-3 (50 and 500 ng) and three doses of NT-4 (50, 500 and 2000 ng) were intracerebroventricularly injected at dark onset. Additionally, 500 ng of each NT were injected during the light period. The electroencephalogram (EEG), brain temperature, and motor activity were recorded for 23 h following NT injection. NT-3 (500 ng dose) and NT-4 (500 and 2000 ng doses) injected at dark onset increased the time spent in non-rapid eye movement sleep. After the 2000 ng dose of NT-4, EEG power was reduced.
AB - We determined if neurotrophins 3 and 4 (NT-3, NT-4) would promote sleep in rabbits. Two doses of NT-3 (50 and 500 ng) and three doses of NT-4 (50, 500 and 2000 ng) were intracerebroventricularly injected at dark onset. Additionally, 500 ng of each NT were injected during the light period. The electroencephalogram (EEG), brain temperature, and motor activity were recorded for 23 h following NT injection. NT-3 (500 ng dose) and NT-4 (500 and 2000 ng doses) injected at dark onset increased the time spent in non-rapid eye movement sleep. After the 2000 ng dose of NT-4, EEG power was reduced.
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U2 - 10.1016/S0304-3940(03)00564-0
DO - 10.1016/S0304-3940(03)00564-0
M3 - Article
C2 - 12853109
AN - SCOPUS:0038306202
SN - 0304-3940
VL - 346
SP - 161
EP - 164
JO - Neuroscience letters
JF - Neuroscience letters
IS - 3
ER -