Neutral Evolution, Population Genetic Tests of

C. D. Huber, K. E. Lohmueller

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Tests of neutrality assess whether patterns of genetic variation are compatible with neutral evolutionary models. They have been successfully used for genome-wide selection scans, yielding important candidate genes for recent adaptation in humans and other species. Here, we present a short overview of commonly used tests of neutrality and the patterns of genetic variation on which they are based. Understanding the performance of particular neutrality tests under various demographic histories and types of selection is crucial for their correct interpretation. Therefore, we place particular emphasis on the specific assumptions of each test.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Evolutionary Biology
PublisherElsevier Inc.
Number of pages7
ISBN (Electronic)9780128004265
ISBN (Print)9780128000496
StatePublished - Apr 14 2016

All Science Journal Classification (ASJC) codes

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology


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