New biologicals to assist clotting

Liang Huang, Christopher Hoffman, Lin Chen, Henry Liu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Severe hemorrhage causes significant metabolic and cellular dysfunction secondary to deficient tissue perfusion and oxygen delivery. If bleeding continues destabilization, hypoxia, multiple organ failure, and death will occur. Techniques employed to promote hemostasis include surgical suture ligatures, cautery, chemical agents, self-assembling nanoparticles, and physical methods like mechanical pressure. Improved understanding of the natural clotting cascade has allowed newly designed agents to become more targeted for clinical and military use. This chapter discusses current and developing hemostatic techniques, including topical matrix agents, biologically inspired agents, intravenous synthetic and cell-derived agents developed with nanotechnology, and external hemostatic dressings.

Original languageEnglish (US)
Title of host publicationEssentials of Blood Product Management in Anesthesia Practice
PublisherSpringer International Publishing
Pages81-88
Number of pages8
ISBN (Electronic)9783030592950
ISBN (Print)9783030592943
DOIs
StatePublished - May 19 2021

All Science Journal Classification (ASJC) codes

  • General Medicine

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