New directions in the biology and therapy of chronic myeloid leukemia

Albert B. Deisseroth, Wei Zhang, Ying Cha, Tianying Yuan, Hanchun Chen, Simon Sims, Andrzej Wedrychowski, Pei Qing Gao, Laurel Huston, Marylynne Filaccio, David Claxton, Steven Kornblau, Elizabeth Johnson, O. M. Zack Howard, Borje Andersson, Auro Del Giglio, Laurent Gressot, Hagop Kantarjian, Moshe Talpaz, Issa KhouriRichard Champlin, Michael Andreeff, Eugenia Gaozza, David Seong, Soon Pal Suh, Debra Ellerson, Guiying Hu, Marian Chou

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Great excitement surrounded the initial discovery of the Philadelphia chromosome translocation and the molecular rearrangement of the abl protooncogene which is generated by this translocation in chronic myelogenous leukemia (CML). In this review, we will discuss how molecular analysis of the biological abnormalities generated in the CML cells by this molecular rearrangement can be applied to new directions in therapy for this disease.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalLeukemia and Lymphoma
Issue number2
StatePublished - 1992

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research


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