TY - JOUR
T1 - New insights into the pathophysiology of diabetic retinopathy
T2 - Potential cell-specific therapeutic targets
AU - Gardner, T. W.
AU - Antonetti, D. A.
AU - Barber, A. J.
AU - LaNoue, K. F.
AU - Nakamura, M.
PY - 2000
Y1 - 2000
N2 - Diabetic retinopathy, a leading cause of vision impairment, is classically defined by its vascular lesions. This review examines how diabetes affects vascular cells, as well as neurons, macroglia, and microglia. The cellular and clinical elements of diabetic retinopathy have many features of chronic inflammation. Understanding the individual cell-specific and global inflammatory changes in the retina may lead to novel therapeutic approaches to prevent vision loss.
AB - Diabetic retinopathy, a leading cause of vision impairment, is classically defined by its vascular lesions. This review examines how diabetes affects vascular cells, as well as neurons, macroglia, and microglia. The cellular and clinical elements of diabetic retinopathy have many features of chronic inflammation. Understanding the individual cell-specific and global inflammatory changes in the retina may lead to novel therapeutic approaches to prevent vision loss.
UR - http://www.scopus.com/inward/record.url?scp=0034468677&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034468677&partnerID=8YFLogxK
U2 - 10.1089/15209150050502023
DO - 10.1089/15209150050502023
M3 - Review article
C2 - 11469624
AN - SCOPUS:0034468677
SN - 1520-9156
VL - 2
SP - 601
EP - 608
JO - Diabetes Technology and Therapeutics
JF - Diabetes Technology and Therapeutics
IS - 4
ER -
