New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans

Fulvio Gala; Maria Valeria D'Auria; Simona De Marino; Franco Zollo; Charles D. Smith; Jean E. Copper; Angela Zampella

doi:10.1016/j.tet.2007.03.162

New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans

Fulvio Gala, Maria Valeria D'Auria, Simona De Marino, Franco Zollo, Charles D. Smith, Jean E. Copper, Angela Zampella

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A reinvestigation of Jaspis splendans afforded the novel compounds jaspamide D-G plus the known compounds jaspamide and jaspamides B and C. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.

Original language	English (US)
Pages (from-to)	5212-5219
Number of pages	8
Journal	Tetrahedron
Volume	63
Issue number	24
DOIs	https://doi.org/10.1016/j.tet.2007.03.162
State	Published - Jun 11 2007

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2007.03.162

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title = "New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans",

abstract = "A reinvestigation of Jaspis splendans afforded the novel compounds jaspamide D-G plus the known compounds jaspamide and jaspamides B and C. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.",

author = "Fulvio Gala and D'Auria, {Maria Valeria} and {De Marino}, Simona and Franco Zollo and Smith, {Charles D.} and Copper, {Jean E.} and Angela Zampella",

year = "2007",

month = jun,

day = "11",

doi = "10.1016/j.tet.2007.03.162",

language = "English (US)",

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AU - Gala, Fulvio

AU - D'Auria, Maria Valeria

AU - De Marino, Simona

AU - Zollo, Franco

AU - Smith, Charles D.

AU - Copper, Jean E.

AU - Zampella, Angela

PY - 2007/6/11

Y1 - 2007/6/11

N2 - A reinvestigation of Jaspis splendans afforded the novel compounds jaspamide D-G plus the known compounds jaspamide and jaspamides B and C. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.

AB - A reinvestigation of Jaspis splendans afforded the novel compounds jaspamide D-G plus the known compounds jaspamide and jaspamides B and C. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.

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DO - 10.1016/j.tet.2007.03.162

M3 - Article

AN - SCOPUS:34247863615

SN - 0040-4020

VL - 63

SP - 5212

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JO - Tetrahedron

JF - Tetrahedron

IS - 24

ER -

New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans

Abstract

All Science Journal Classification (ASJC) codes

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