New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans

Fulvio Gala; Maria Valeria D'Auria; Simona De Marino; Franco Zollo; Charles D. Smith; Jean E. Copper; Angela Zampella

doi:10.1016/j.tet.2007.03.162

New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans

Fulvio Gala
, Maria Valeria D'Auria
, Simona De Marino
, Franco Zollo
, Charles D. Smith
, Jean E. Copper
, Angela Zampella

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A reinvestigation of Jaspis splendans afforded the novel compounds jaspamide D-G plus the known compounds jaspamide and jaspamides B and C. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.

Original language	English (US)
Pages (from-to)	5212-5219
Number of pages	8
Journal	Tetrahedron
Volume	63
Issue number	24
DOIs	https://doi.org/10.1016/j.tet.2007.03.162
State	Published - Jun 11 2007

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2007.03.162

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title = "New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans",

abstract = "A reinvestigation of Jaspis splendans afforded the novel compounds jaspamide D-G plus the known compounds jaspamide and jaspamides B and C. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.",

author = "Fulvio Gala and D'Auria, \{Maria Valeria\} and \{De Marino\}, Simona and Franco Zollo and Smith, \{Charles D.\} and Copper, \{Jean E.\} and Angela Zampella",

year = "2007",

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doi = "10.1016/j.tet.2007.03.162",

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T1 - New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans

AU - Gala, Fulvio

AU - D'Auria, Maria Valeria

AU - De Marino, Simona

AU - Zollo, Franco

AU - Smith, Charles D.

AU - Copper, Jean E.

AU - Zampella, Angela

PY - 2007/6/11

Y1 - 2007/6/11

N2 - A reinvestigation of Jaspis splendans afforded the novel compounds jaspamide D-G plus the known compounds jaspamide and jaspamides B and C. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.

AB - A reinvestigation of Jaspis splendans afforded the novel compounds jaspamide D-G plus the known compounds jaspamide and jaspamides B and C. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.

UR - https://www.scopus.com/pages/publications/34247863615

UR - https://www.scopus.com/pages/publications/34247863615#tab=citedBy

U2 - 10.1016/j.tet.2007.03.162

DO - 10.1016/j.tet.2007.03.162

M3 - Article

AN - SCOPUS:34247863615

SN - 0040-4020

VL - 63

SP - 5212

EP - 5219

JO - Tetrahedron

JF - Tetrahedron

IS - 24

ER -

New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans

Abstract

All Science Journal Classification (ASJC) codes

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