TY - JOUR
T1 - Newly constructed insecticide-resistant D. melanogaster strains with elevated sensitivity to the mutagenic effect of benzo(a)pyrene and 2-acethylaminofluorene
AU - Dobrovolskaya, M. A.
AU - Spiegelman, V. S.
AU - Belitsky, G. A.
PY - 1997/9
Y1 - 1997/9
N2 - The mutagenic effect of a number of procarcinogenic compounds has been compared in two groups of Drosophila melanogaster strains differing in the insecticide resistance-associated cytochrome P-450. Heterozygotes y++/+wsn3 of insecticide-sensitive strains were shown to be sensitive to the mutagenic effects of aflatoxin B1, 1,2-dibromo-3-chloropropane and nitrozamines, but failed to detect mutagenicity of the benzo(a)pyrene and acethylaminofluorenes. In contrast, the newly established DDT-resistant strains were found to be sensitive to the mutagenecity of BP and 2- AAF in the SMART assay. Mechanisms of the sensitivity of the newly constructed strains to BP and 2-AAF are discussed.
AB - The mutagenic effect of a number of procarcinogenic compounds has been compared in two groups of Drosophila melanogaster strains differing in the insecticide resistance-associated cytochrome P-450. Heterozygotes y++/+wsn3 of insecticide-sensitive strains were shown to be sensitive to the mutagenic effects of aflatoxin B1, 1,2-dibromo-3-chloropropane and nitrozamines, but failed to detect mutagenicity of the benzo(a)pyrene and acethylaminofluorenes. In contrast, the newly established DDT-resistant strains were found to be sensitive to the mutagenecity of BP and 2- AAF in the SMART assay. Mechanisms of the sensitivity of the newly constructed strains to BP and 2-AAF are discussed.
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M3 - Article
AN - SCOPUS:3342966887
SN - 0204-3564
VL - 19
SP - 185
EP - 190
JO - Experimental Oncology
JF - Experimental Oncology
IS - 3
ER -
