TY - JOUR
T1 - Next Steps in Integrative Biology
T2 - Mapping Interactive Processes Across Levels of Biological Organization
AU - Cavigelli, Sonia
AU - Leips, Jeff
AU - Xiang, Qiu Yun (Jenny)
AU - Lemke, Dawn
AU - Konow, Nicolai
N1 - Publisher Copyright:
© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Emergent biological processes result from complex interactions within and across levels of biological organization, ranging from molecular to environmental dynamics. Powerful theories, database tools, and modeling methods have been designed to characterize network connections within levels, such as those among genes, proteins, biochemicals, cells, organisms, and species. Here, we propose that developing integrative models of organismal function in complex environments can be facilitated by taking advantage of these methods to identify key nodes of communication across levels of organization. Mapping key drivers or connections among levels of organization will provide data and leverage to model potential rule-sets by which organisms respond and adjust to perturbations at any level of biological organization.
AB - Emergent biological processes result from complex interactions within and across levels of biological organization, ranging from molecular to environmental dynamics. Powerful theories, database tools, and modeling methods have been designed to characterize network connections within levels, such as those among genes, proteins, biochemicals, cells, organisms, and species. Here, we propose that developing integrative models of organismal function in complex environments can be facilitated by taking advantage of these methods to identify key nodes of communication across levels of organization. Mapping key drivers or connections among levels of organization will provide data and leverage to model potential rule-sets by which organisms respond and adjust to perturbations at any level of biological organization.
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U2 - 10.1093/icb/icab161
DO - 10.1093/icb/icab161
M3 - Article
C2 - 34259855
AN - SCOPUS:85124433482
SN - 1540-7063
VL - 61
SP - 2066
EP - 2074
JO - Integrative and comparative biology
JF - Integrative and comparative biology
IS - 6
ER -