Abstract
We disclose a Ni-catalyzed vicinal alkylarylation of unactivated alkenes in γ,δ-alkenylketimines with aryl halides and alkylzinc reagents. The reaction produces γ-C(sp3)-branched δ-arylketones with the construction of two C(sp3)-C(sp3) and C(sp3)-C(sp2) bonds. Electron-deficient alkenes play crucial dual roles as ligands to stabilize reaction intermediates and to increase catalytic rates for the formation of C(sp3)-C(sp3) bonds. This alkene alkylarylation reaction is also effective for secondary alkylzinc reagents and internal alkenes and proceeds with a complete regio- and stereocontrol, affording products with up to three contiguous all-carbon all-cis secondary stereocenters.
Original language | English (US) |
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Pages (from-to) | 7262-7268 |
Number of pages | 7 |
Journal | ACS Catalysis |
Volume | 12 |
Issue number | 12 |
DOIs | |
State | Published - Jun 17 2022 |
All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)