TY - JOUR
T1 - Nicotine enhances both foreground and background contextual fear conditioning
AU - Davis, Jennifer A.
AU - Porter, Jessica
AU - Gould, Thomas J.
N1 - Funding Information:
The authors would like to acknowledge grant support from the National Institute on Drug Abuse (DA017949 T.G.), the Pennsylvania Department of Health (T.G.), and Temple University (T.G.). Jennifer Davis was supported by a NIH/NIDA training grant (T32DA07237). Part of this study was Miss Jessica Porter's undergraduate research.
PY - 2006/2/20
Y1 - 2006/2/20
N2 - The present study examined if nicotine enhances contextual fear conditioning when the training context is either a background stimulus or a foreground stimulus. In the background conditioning experiment, mice were trained using two auditory conditioned stimulus (CS; 30 s, 85 dB white noise)-footshock unconditioned stimulus (US; 2 s, 0.57 mA) pairings and tested 24 h later. In the foreground conditioning experiment, mice were trained with two presentations of a footshock US (2 s, 0.57 mA) and tested 24 h later. Mice received 0.09 mg/kg nicotine before training and testing. For both the foreground and background conditioning experiments, nicotine enhanced contextual conditioning. No enhancement of the auditory CS-US association was seen. These results demonstrate that nicotine enhances contextual fear conditioning regardless of whether the context is a background stimulus or a foreground stimulus during conditioning.
AB - The present study examined if nicotine enhances contextual fear conditioning when the training context is either a background stimulus or a foreground stimulus. In the background conditioning experiment, mice were trained using two auditory conditioned stimulus (CS; 30 s, 85 dB white noise)-footshock unconditioned stimulus (US; 2 s, 0.57 mA) pairings and tested 24 h later. In the foreground conditioning experiment, mice were trained with two presentations of a footshock US (2 s, 0.57 mA) and tested 24 h later. Mice received 0.09 mg/kg nicotine before training and testing. For both the foreground and background conditioning experiments, nicotine enhanced contextual conditioning. No enhancement of the auditory CS-US association was seen. These results demonstrate that nicotine enhances contextual fear conditioning regardless of whether the context is a background stimulus or a foreground stimulus during conditioning.
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U2 - 10.1016/j.neulet.2005.10.026
DO - 10.1016/j.neulet.2005.10.026
M3 - Article
C2 - 16260086
AN - SCOPUS:31344464452
SN - 0304-3940
VL - 394
SP - 202
EP - 205
JO - Neuroscience letters
JF - Neuroscience letters
IS - 3
ER -