Nicotine enhances latent inhibition and ameliorates ethanol-induced deficits in latent inhibition

T. J. Gould, A. C. Collins, J. M. Wehner

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Alcohol and nicotine are drugs of abuse that are used frequently together. One possible explanation for this co-administration is that nicotine prevents or lessens alcohol-associated impairments. The present study examined the dose-dependent effects of acute administration of nicotine, alcohol, or alcohol plus nicotine on latent inhibition as measured by lick suppression in C57BL/6 mice. Alterations in a lick suppression ratio were measured by assessing the effects of 10 pre-exposures to an auditory conditioned stimulus (CS) on formation of subsequent CS-shock unconditioned stimulus (US) associations. Mice pre-exposed to the CS were expected to develop a weaker CS-US association. Nicotine administered prior to pre-exposure to the CS produced increased suppression ratios, ethanol given prior to pre-exposure to the CS decreased suppression ratios, and nicotine reversed the effects of ethanol when the two drugs were co-administered. These opposing actions of nicotine and ethanol may have relevance to the high incidence of smoking and drinking in humans.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalNicotine and Tobacco Research
Issue number1
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health


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