TY - JOUR
T1 - Nicotine from cigarette smoking and diet and Parkinson disease
T2 - A review
AU - Ma, Chaoran
AU - Liu, Yesong
AU - Neumann, Samantha
AU - Gao, Xiang
N1 - Funding Information:
This work was supported by the National Institute of Neurological Disorders and Stroke at the National Institutes of Health (NINDS R03 NS093245 01A1 and NINDS/NIH 1R21NS087235-01A1 to to X.G.).
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/7/2
Y1 - 2017/7/2
N2 - Evidence from epidemiological studies suggest a relationship between cigarette smoking and low risk of Parkinson disease (PD). As a major component of tobacco smoke, nicotine has been proposed to be a substance for preventing against PD risk, with a key role in regulating striatal activity and behaviors mediated through the dopaminergic system. Animal studies also showed that nicotine could modulate dopamine transmission and reduce levodopa-induced dyskinesias. However, previous clinical trials yield controversial results regarding nicotine treatment. In this review, we updated epidemiological, preclinical and clinical data, and studies on nicotine from diet. We also reviewed interactions between genetic factors and cigarette smoking. As a small amount of nicotine can saturate a substantial portion of nicotine receptors in the brain, nicotine from other sources, such as diet, could be a promising therapeutic substance for protection against PD.
AB - Evidence from epidemiological studies suggest a relationship between cigarette smoking and low risk of Parkinson disease (PD). As a major component of tobacco smoke, nicotine has been proposed to be a substance for preventing against PD risk, with a key role in regulating striatal activity and behaviors mediated through the dopaminergic system. Animal studies also showed that nicotine could modulate dopamine transmission and reduce levodopa-induced dyskinesias. However, previous clinical trials yield controversial results regarding nicotine treatment. In this review, we updated epidemiological, preclinical and clinical data, and studies on nicotine from diet. We also reviewed interactions between genetic factors and cigarette smoking. As a small amount of nicotine can saturate a substantial portion of nicotine receptors in the brain, nicotine from other sources, such as diet, could be a promising therapeutic substance for protection against PD.
UR - http://www.scopus.com/inward/record.url?scp=85021636304&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021636304&partnerID=8YFLogxK
U2 - 10.1186/s40035-017-0090-8
DO - 10.1186/s40035-017-0090-8
M3 - Review article
C2 - 28680589
AN - SCOPUS:85021636304
SN - 2047-9158
VL - 6
JO - Translational Neurodegeneration
JF - Translational Neurodegeneration
IS - 1
M1 - 18
ER -