Nicotine from cigarette smoking and diet and Parkinson disease: A review

Chaoran Ma, Yesong Liu, Samantha Neumann, Xiang Gao

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations


Evidence from epidemiological studies suggest a relationship between cigarette smoking and low risk of Parkinson disease (PD). As a major component of tobacco smoke, nicotine has been proposed to be a substance for preventing against PD risk, with a key role in regulating striatal activity and behaviors mediated through the dopaminergic system. Animal studies also showed that nicotine could modulate dopamine transmission and reduce levodopa-induced dyskinesias. However, previous clinical trials yield controversial results regarding nicotine treatment. In this review, we updated epidemiological, preclinical and clinical data, and studies on nicotine from diet. We also reviewed interactions between genetic factors and cigarette smoking. As a small amount of nicotine can saturate a substantial portion of nicotine receptors in the brain, nicotine from other sources, such as diet, could be a promising therapeutic substance for protection against PD.

Original languageEnglish (US)
Article number18
JournalTranslational Neurodegeneration
Issue number1
StatePublished - Jul 2 2017

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience


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