NMDA Receptor Antagonists in the Treatment of Pain

Y. Vorobeychik; C. D. Willoughby; J. Mao

doi:10.1007/978-1-4939-1818-8_6

NMDA Receptor Antagonists in the Treatment of Pain

Y. Vorobeychik, C. D. Willoughby, J. Mao

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Over the past three decades, the central glutamatergic system, particularly the role of the N-methyl-D-aspartate (NMDA) receptor in the neural mechanisms of persistent pain, has been extensively investigated. Chronic pain can be sustained by way of a central sensitization process involving the NMDA receptor system. Data from preclinical studies have consistently supported a crucial role of the central glutamatergic system and NMDA receptors in the induction and maintenance of persistent pain resulting from pathological conditions such as inflammation and nerve injury. To date, clinical trials have resulted in mixed conclusions as to the overall effectiveness in treating persistent pain with NMDA receptor antagonists. Nonetheless, NMDA receptor antagonists have been demonstrated as an effective treatment option in the management of chronic pain, particularly for pain which has been refractory to other treatment modalities.

Original language	English (US)
Title of host publication	Treatment of Chronic Pain by Medical Approaches the American Academy of Pain Medicine Textbook on Patient Management
Publisher	Springer New York
Pages	59-65
Number of pages	7
ISBN (Electronic)	9781493918188
ISBN (Print)	9781493918171
DOIs	https://doi.org/10.1007/978-1-4939-1818-8_6
State	Published - Jan 1 2014

All Science Journal Classification (ASJC) codes

General Medicine

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10.1007/978-1-4939-1818-8_6

Cite this

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NMDA Receptor Antagonists in the Treatment of Pain

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