NMR solution structures of adducts derived from the binding of polycyclic aromatic diol epoxides to DNA

M. Cosman; B. E. Hingerty; S. Amin; S. Broyde; N. E. Geacintov; D. J. Patel

doi:10.1080/10406639608034692

NMR solution structures of adducts derived from the binding of polycyclic aromatic diol epoxides to DNA

M. Cosman
, B. E. Hingerty
, S. Amin
, S. Broyde
, N. E. Geacintov
, D. J. Patel

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Site-specifically modified oligonucleotides were derived from the reactions of stereoisomeric polycyclic aromatic diol epoxide metabolite model compounds with oligonucleotides of defined base composition and sequence. The NMR solution structures of ten different adducts studied so far are briefly described, and it is shown that stereochemical factors and the nature of the oligonucleotide context of the complementary strands, exert a powerful influence on the conformational features of these adducts.

Original language	English (US)
Pages (from-to)	153-160
Number of pages	8
Journal	Polycyclic Aromatic Compounds
Volume	10
Issue number	1-4
DOIs	https://doi.org/10.1080/10406639608034692
State	Published - 1996

All Science Journal Classification (ASJC) codes

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1080/10406639608034692

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title = "NMR solution structures of adducts derived from the binding of polycyclic aromatic diol epoxides to DNA",

abstract = "Site-specifically modified oligonucleotides were derived from the reactions of stereoisomeric polycyclic aromatic diol epoxide metabolite model compounds with oligonucleotides of defined base composition and sequence. The NMR solution structures of ten different adducts studied so far are briefly described, and it is shown that stereochemical factors and the nature of the oligonucleotide context of the complementary strands, exert a powerful influence on the conformational features of these adducts.",

author = "M. Cosman and Hingerty, \{B. E.\} and S. Amin and S. Broyde and Geacintov, \{N. E.\} and Patel, \{D. J.\}",

note = "Funding Information: This work was supported by NIH Grants CA 46533 (D.J.P.), CA 20851 (N.E.G.), CA 28038 (S.B.) and by the Department of Energy Grants DE-FG02-86ER-60405 (N.E.G.) and DE-FG02-90ER60931 (S.B.), and DOE Contract DE-AC05-840R21400 with Martin-Marietta Energy Systems and DOE OHER Field work Proposal ERKP931 to B.E.H. Computations were carried out at NERSC (DOE) and SDSC (NSF).",

year = "1996",

doi = "10.1080/10406639608034692",

language = "English (US)",

volume = "10",

pages = "153--160",

journal = "Polycyclic Aromatic Compounds",

issn = "1040-6638",

publisher = "Taylor and Francis Ltd.",

number = "1-4",

}

TY - JOUR

T1 - NMR solution structures of adducts derived from the binding of polycyclic aromatic diol epoxides to DNA

AU - Cosman, M.

AU - Hingerty, B. E.

AU - Amin, S.

AU - Broyde, S.

AU - Geacintov, N. E.

AU - Patel, D. J.

N1 - Funding Information: This work was supported by NIH Grants CA 46533 (D.J.P.), CA 20851 (N.E.G.), CA 28038 (S.B.) and by the Department of Energy Grants DE-FG02-86ER-60405 (N.E.G.) and DE-FG02-90ER60931 (S.B.), and DOE Contract DE-AC05-840R21400 with Martin-Marietta Energy Systems and DOE OHER Field work Proposal ERKP931 to B.E.H. Computations were carried out at NERSC (DOE) and SDSC (NSF).

PY - 1996

Y1 - 1996

N2 - Site-specifically modified oligonucleotides were derived from the reactions of stereoisomeric polycyclic aromatic diol epoxide metabolite model compounds with oligonucleotides of defined base composition and sequence. The NMR solution structures of ten different adducts studied so far are briefly described, and it is shown that stereochemical factors and the nature of the oligonucleotide context of the complementary strands, exert a powerful influence on the conformational features of these adducts.

AB - Site-specifically modified oligonucleotides were derived from the reactions of stereoisomeric polycyclic aromatic diol epoxide metabolite model compounds with oligonucleotides of defined base composition and sequence. The NMR solution structures of ten different adducts studied so far are briefly described, and it is shown that stereochemical factors and the nature of the oligonucleotide context of the complementary strands, exert a powerful influence on the conformational features of these adducts.

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U2 - 10.1080/10406639608034692

DO - 10.1080/10406639608034692

M3 - Article

AN - SCOPUS:0030366314

SN - 1040-6638

VL - 10

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EP - 160

JO - Polycyclic Aromatic Compounds

JF - Polycyclic Aromatic Compounds

IS - 1-4

ER -

NMR solution structures of adducts derived from the binding of polycyclic aromatic diol epoxides to DNA

Abstract

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