No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene

Stephen A. Petrill; Robert Plomin; Gerald E. McClearn; Deborah L. Smith; Sylvia Vignetti; Michael J. Chorney; Karen Chorney; Lee A. Thompson; Douglas K. Detterman; Camilla Benbow; David Lubinski; Joanna Daniels; Michael Owen; Peter McGuffin

doi:10.1023/A:1025659124405

No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene

Stephen A. Petrill, Robert Plomin, Gerald E. McClearn, Deborah L. Smith, Sylvia Vignetti, Michael J. Chorney, Karen Chorney, Lee A. Thompson, Douglas K. Detterman, Camilla Benbow, David Lubinski, Joanna Daniels, Michael Owen, Peter McGuffin

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30 Scopus citations

Abstract

Berman and Noble (1995) reported significantly reduced visuospatial performance in children with the TAQI A1 allele of the D2 dopamine receptor (DRD2) gene. Given that visuospatial performance loads highly on an unrotated principal component indexing general cognitive ability, we tested the association between DRD2 and WISC-R IQ comparing 51 high-IQ, 51 average-IQ, and 35 low-IQ children in the IQ Quantitative Trait Loci (QTL) Project. No statistically significant association between the TAQI A DRD2 alleles and IQ was found. Given that a statistically significant portion of genetic variance for specific cognitive abilities is independent of general cognitive ability, it is possible that the TAQI DRD2 association is specific to visuospatial performance and independent of general cognitive ability.

Original language	English (US)
Pages (from-to)	29-31
Number of pages	3
Journal	Behavior Genetics
Volume	27
Issue number	1
DOIs	https://doi.org/10.1023/A:1025659124405
State	Published - 1997

All Science Journal Classification (ASJC) codes

Ecology, Evolution, Behavior and Systematics
Genetics
Genetics(clinical)

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Petrill, S. A., Plomin, R., McClearn, G. E., Smith, D. L., Vignetti, S., Chorney, M. J., Chorney, K., Thompson, L. A., Detterman, D. K., Benbow, C., Lubinski, D., Daniels, J., Owen, M., & McGuffin, P. (1997). No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene. Behavior Genetics, 27(1), 29-31. https://doi.org/10.1023/A:1025659124405

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title = "No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene",

abstract = "Berman and Noble (1995) reported significantly reduced visuospatial performance in children with the TAQI A1 allele of the D2 dopamine receptor (DRD2) gene. Given that visuospatial performance loads highly on an unrotated principal component indexing general cognitive ability, we tested the association between DRD2 and WISC-R IQ comparing 51 high-IQ, 51 average-IQ, and 35 low-IQ children in the IQ Quantitative Trait Loci (QTL) Project. No statistically significant association between the TAQI A DRD2 alleles and IQ was found. Given that a statistically significant portion of genetic variance for specific cognitive abilities is independent of general cognitive ability, it is possible that the TAQI DRD2 association is specific to visuospatial performance and independent of general cognitive ability.",

author = "Petrill, {Stephen A.} and Robert Plomin and McClearn, {Gerald E.} and Smith, {Deborah L.} and Sylvia Vignetti and Chorney, {Michael J.} and Karen Chorney and Thompson, {Lee A.} and Detterman, {Douglas K.} and Camilla Benbow and David Lubinski and Joanna Daniels and Michael Owen and Peter McGuffin",

note = "Funding Information: The current study is supported by Grant HD-27694 from the U.S. National Institute of Child Health and Human Development (NICHD). Dr. Pe-trill is supported by a postdoctoral fellowship from the NICHD (HD-07454) at The Pennsylvania State University.",

year = "1997",

doi = "10.1023/A:1025659124405",

language = "English (US)",

volume = "27",

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T1 - No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene

AU - Petrill, Stephen A.

AU - Plomin, Robert

AU - McClearn, Gerald E.

AU - Smith, Deborah L.

AU - Vignetti, Sylvia

AU - Chorney, Michael J.

AU - Chorney, Karen

AU - Thompson, Lee A.

AU - Detterman, Douglas K.

AU - Benbow, Camilla

AU - Lubinski, David

AU - Daniels, Joanna

AU - Owen, Michael

AU - McGuffin, Peter

N1 - Funding Information: The current study is supported by Grant HD-27694 from the U.S. National Institute of Child Health and Human Development (NICHD). Dr. Pe-trill is supported by a postdoctoral fellowship from the NICHD (HD-07454) at The Pennsylvania State University.

PY - 1997

Y1 - 1997

N2 - Berman and Noble (1995) reported significantly reduced visuospatial performance in children with the TAQI A1 allele of the D2 dopamine receptor (DRD2) gene. Given that visuospatial performance loads highly on an unrotated principal component indexing general cognitive ability, we tested the association between DRD2 and WISC-R IQ comparing 51 high-IQ, 51 average-IQ, and 35 low-IQ children in the IQ Quantitative Trait Loci (QTL) Project. No statistically significant association between the TAQI A DRD2 alleles and IQ was found. Given that a statistically significant portion of genetic variance for specific cognitive abilities is independent of general cognitive ability, it is possible that the TAQI DRD2 association is specific to visuospatial performance and independent of general cognitive ability.

AB - Berman and Noble (1995) reported significantly reduced visuospatial performance in children with the TAQI A1 allele of the D2 dopamine receptor (DRD2) gene. Given that visuospatial performance loads highly on an unrotated principal component indexing general cognitive ability, we tested the association between DRD2 and WISC-R IQ comparing 51 high-IQ, 51 average-IQ, and 35 low-IQ children in the IQ Quantitative Trait Loci (QTL) Project. No statistically significant association between the TAQI A DRD2 alleles and IQ was found. Given that a statistically significant portion of genetic variance for specific cognitive abilities is independent of general cognitive ability, it is possible that the TAQI DRD2 association is specific to visuospatial performance and independent of general cognitive ability.

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No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene

Abstract

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