No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

Lynette S. Phillips; Cheryl L. Thompson; Alona Merkulova; Sarah J. Plummer; Thomas C. Tucker; Graham Casey; Li Li

doi:10.3748/wjg.15.3771

No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

Lynette S. Phillips
, Cheryl L. Thompson
, Alona Merkulova
, Sarah J. Plummer
, Thomas C. Tucker
, Graham Casey
, Li Li

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.

Original language	English (US)
Pages (from-to)	3771-3775
Number of pages	5
Journal	World journal of gastroenterology
Volume	15
Issue number	30
DOIs	https://doi.org/10.3748/wjg.15.3771
State	Published - 2009

All Science Journal Classification (ASJC) codes

Gastroenterology

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10.3748/wjg.15.3771

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title = "No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer",

abstract = "AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.",

author = "Phillips, \{Lynette S.\} and Thompson, \{Cheryl L.\} and Alona Merkulova and Plummer, \{Sarah J.\} and Tucker, \{Thomas C.\} and Graham Casey and Li Li",

year = "2009",

doi = "10.3748/wjg.15.3771",

language = "English (US)",

volume = "15",

pages = "3771--3775",

journal = "World journal of gastroenterology",

issn = "1007-9327",

publisher = "Baishideng Publishing Group Inc",

number = "30",

}

TY - JOUR

T1 - No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

AU - Phillips, Lynette S.

AU - Thompson, Cheryl L.

AU - Merkulova, Alona

AU - Plummer, Sarah J.

AU - Tucker, Thomas C.

AU - Casey, Graham

AU - Li, Li

PY - 2009

Y1 - 2009

N2 - AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.

AB - AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.

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UR - https://www.scopus.com/pages/publications/70350458592#tab=citedBy

U2 - 10.3748/wjg.15.3771

DO - 10.3748/wjg.15.3771

M3 - Article

C2 - 19673018

AN - SCOPUS:70350458592

SN - 1007-9327

VL - 15

SP - 3771

EP - 3775

JO - World journal of gastroenterology

JF - World journal of gastroenterology

IS - 30

ER -

No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

Abstract

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