TY - JOUR
T1 - Nonmuscle myosin heavy chain B is recognized by a monoclonal antibody that inhibits GM1-enhanced neuritogenesis
AU - Mummert, Christine M.
AU - Schengrund, Cara Lynne
PY - 1997/2
Y1 - 1997/2
N2 - Addition of gangliosides to neuroblastoma cells maintained in vitro has been shown to enhance neuritogenesis. Although the mechanism by which they exert this effect is unknown, it has been postulated that they may act by adhering to cell surface proteins. In this article, we describe the isolation and identification of an S20Y murine neuroblastoma cell protein recognized by a monoclonal antibody that was prepared against putative GM1-binding proteins and shown to inhibit GM1-enhanced neuritogenesis. The protein identified was nonmuscle myosin heavy chain B, which appears to function in neurite formation but may not adhere to gangliosides.
AB - Addition of gangliosides to neuroblastoma cells maintained in vitro has been shown to enhance neuritogenesis. Although the mechanism by which they exert this effect is unknown, it has been postulated that they may act by adhering to cell surface proteins. In this article, we describe the isolation and identification of an S20Y murine neuroblastoma cell protein recognized by a monoclonal antibody that was prepared against putative GM1-binding proteins and shown to inhibit GM1-enhanced neuritogenesis. The protein identified was nonmuscle myosin heavy chain B, which appears to function in neurite formation but may not adhere to gangliosides.
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U2 - 10.1046/j.1471-4159.1997.68020596.x
DO - 10.1046/j.1471-4159.1997.68020596.x
M3 - Article
C2 - 9003045
AN - SCOPUS:0031013107
SN - 0022-3042
VL - 68
SP - 596
EP - 600
JO - Journal of neurochemistry
JF - Journal of neurochemistry
IS - 2
ER -