Normal values of regional left ventricular endocardial motion: Multicenter color kinesis study

Victor Mor-Avi, Kirk Spencer, John Gorcsan, Anthony Demaria, Thomas Kimball, Mark Monaghan, Julio Perez, Jing Ping Sun, Lynn Weinert, James Bednarz, Keith Collins, Kathy Edelman, Oi Ling Kwan, Betty Glascock, Jane Hancock, Chris Baumann, James Thomas, Roberto Lang

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Our goal was to establish normal values for quantitative color kinesis indexes of left ventricular (LV) wall motion over a wide range of ages, which are required for objective diagnosis of regional systolic and diastolic dysfunction. Color-encoded images were obtained in 194 normal subjects (95 males, 99 females, age 2 mo to 79 yr) in four standard views. Quantitative indexes of magnitude and timing of systolic and diastolic function were studied for age- and gender-related differences. Normal limits of all ejection and filling indexes were in a narrow range (≤25% of the mean), with no major gender-related differences. Despite invariable ejection fractions, both peak filling and ejection rates decreased with age (30 and 20%, correspondingly) with a concomitant increase in mean filling and ejection times, resulting in five-and twofold increases in the late to early filling and ejection ratios, correspondingly. Diastolic asynchrony increased with age (from 4.7 ± 2.0 to 6.4 ± 3.2 from the 2nd to 7th decade). The normal values of color kinesis indexes should allow objective detection of regional LV systolic and diastolic dysfunction.

Original languageEnglish (US)
Pages (from-to)H2464-H2476
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number5 48-5
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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