Novel anti-factor D monoclonal antibody inhibits complement and leukocyte activation in a baboon model of cardiopulmonary bypass

Keyphrases

• Monoclonal Antibody 100%
• Cardiopulmonary Bypass 100%
• Complement Activation 100%
• Anti-factor D 100%
• Leukocyte Recruitment 100%
• Treatment Group 23%
• Tissue Injury 23%
• Creatine kinase-MB (CK-MB) 23%
• Systemic Inflammation 23%
• Interleukin-6 15%
• Baboon 15%
• Alternative Complement Pathway 15%
• Creatine Kinase 15%
• Flow Cytometry 7%
• Human Factors 7%
• Core Cooling 7%
• Rectal Temperature 7%
• Hypothermic Cardiopulmonary Bypass 7%
• Rewarming 7%
• Normothermic Cardiopulmonary Bypass 7%
• Blood Samples 7%
• Multiple Injections 7%
• Neutrophils 7%
• Neutrophil Activation 7%
• Adverse Outcomes 7%
• Alternative Pathway 7%
• Monocytes 7%
• Monocyte Activation 7%
• Murine Antibody 7%
• Novel Antibodies 7%
• Inflammation Injury 7%
• Saline Solution 7%
• Aortic Cross-clamping 7%

Immunology and Microbiology

• Complement Activation 100%
• Monoclonal Antibody 100%
• Leukocyte Activation 100%
• Factor D 100%
• Systemic Inflammation 50%
• Blood Plasma 33%
• Interleukin 6 33%
• Monocyte 33%
• Alternative Complement Pathway 33%
• Solution and Solubility 16%
• ELISA 16%
• Neutrophil Granulocyte 16%
• Neutrophil 16%
• Rectal Temperature 16%
• Complement Component C4d 16%
• Aortic Clamping 16%
• Warming 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Monoclonal Antibody 100%
• Inflammation 50%
• Tissue Injury 50%
• Creatine Kinase MB 50%
• Interleukin 6 33%
• Lactate Dehydrogenase 33%
• Complement Component C3a 33%
• Isoenzyme 33%
• Flow Cytometry 16%
• Enzyme-Linked Immunosorbent Assay 16%
• Sodium Chloride 16%
• Adverse Outcome 16%
• Creatine Kinase 16%
• Complement Component C4d 16%
• Creatine Kinase Isoenzyme 16%