Novel Citric Acid-Based Biodegradable Elastomers for Tissue Engineering

Jian Yang, Antonio R. Webb, Guillermo A. Ameer

Research output: Contribution to journalArticlepeer-review

508 Scopus citations


The synthesis and characterization of a novel biodegradable elastomer, poly(1,8-octanediol-co-citric acid) (POC), for use in tissue engineering were described. Citric acid was chosen as a polyfunctional monomer because it is a non-toxic metabolic product of the body. Tubular and sponge-like POC scaffolds with inter-connected pore structures were fabricated using molds and salt leaching technique. The results suggest that POC tube scaffolds are strong enough to act as a temporary template for blood vessels engineered in vivo.

Original languageEnglish (US)
Pages (from-to)511-516
Number of pages6
JournalAdvanced Materials
Issue number6
StatePublished - Mar 18 2004

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering


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