TY - JOUR
T1 - Novel CNS-directed drug delivery systems in Alzheimer's disease and other neurological disorders
AU - Harbaugh, Robert E.
N1 - Funding Information:
Studies of CNS drug delivery at Dartmouth have been supported by National Institute of Mental Health grant 1R 01-40505~ I and grants from the American Health Assistance Foundation, NATO. Pfizer Corporation and Shiley-lnfusaid, Inc. I would also like to thank M. Sean Grady, MD. for information regarding implantable polymers.
PY - 1989
Y1 - 1989
N2 - Increasing knowledge of the neurochemical aspects of central nervous system function raises the possibility of treating Alzheimer's disease (AD) and other neurological diseases by the appropriate manipulation of neurotransmitters, neuromodulators, neurohormones or neurotrophic factors. Clinical application of this knowledge may, however, be inhibited by long standing problems with drug delivery to the central nervous system (CNS). Novel, CNS-directed, drug delivery systems might be used to overcome many of these problems. The problems encountered in drug delivery to the brain, present experience with the clinical use of some novel drug delivery systems and the advantages and disadvantages of these systems will be discussed.
AB - Increasing knowledge of the neurochemical aspects of central nervous system function raises the possibility of treating Alzheimer's disease (AD) and other neurological diseases by the appropriate manipulation of neurotransmitters, neuromodulators, neurohormones or neurotrophic factors. Clinical application of this knowledge may, however, be inhibited by long standing problems with drug delivery to the central nervous system (CNS). Novel, CNS-directed, drug delivery systems might be used to overcome many of these problems. The problems encountered in drug delivery to the brain, present experience with the clinical use of some novel drug delivery systems and the advantages and disadvantages of these systems will be discussed.
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U2 - 10.1016/0197-4580(89)90155-3
DO - 10.1016/0197-4580(89)90155-3
M3 - Review article
C2 - 2572986
AN - SCOPUS:0024343229
SN - 0197-4580
VL - 10
SP - 623
EP - 629
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 5
ER -