TY - JOUR
T1 - Novel implication of the prolactin (PRL) gene in the comorbidity of type 2 diabetes and depression
AU - Amin, M.
AU - Wu, R.
AU - Postolache, T. T.
AU - Gragnoli, C.
N1 - Funding Information:
This publication was supported in part with the funds received under Nebraska Laws 2021, LB 380, Section 109 awarded to C.G. (PI), Creighton University School of Medicine, through the Nebraska Department of Health & Human Services (DHHS). Its contents represent the views of the authors and do not necessarily represent the official views of the State of Nebraska or DHHS.
Publisher Copyright:
© 2023 Verduci Editore s.r.l. All rights reserved.
PY - 2023
Y1 - 2023
N2 - OBJECTIVE: The prolactin (PRL) system plays important behavioral, social, and metabolic roles, such as mediating social bonding and insulin secretion. Inherited dysfunction of the PRL pathway-related genes is associated with psychopathology and insulin resistance. We have previously suggested that the PRL system might be implicated in the comorbidity of psychiatric (depression) and type 2 diabetes (T2D) owing to the pleiotropy of PRL pathway-related genes. To our knowledge, no PRL variants have so far been reported in patients with either major depressive disorder (MDD) and/or T2D. PATIENTS AND METHODS: In this study, we analyzed 6 variants within the PRL gene and tested them for the presence of parametric linkage and/or linkage disequilibrium (LD, i.e., linkage and association) with familial MDD, T2D, and their comorbidity. RESULTS: We found, for the first time, that the PRL gene and its novel risk variants are linked to and in LD (i.e., linkage and association) with familial MDD, T2D, and MDD-T2D comorbidity. CONCLUSIONS: PRL might play a key role in mental-metabolic comorbidity and can be considered a novel gene in MDD and T2D.
AB - OBJECTIVE: The prolactin (PRL) system plays important behavioral, social, and metabolic roles, such as mediating social bonding and insulin secretion. Inherited dysfunction of the PRL pathway-related genes is associated with psychopathology and insulin resistance. We have previously suggested that the PRL system might be implicated in the comorbidity of psychiatric (depression) and type 2 diabetes (T2D) owing to the pleiotropy of PRL pathway-related genes. To our knowledge, no PRL variants have so far been reported in patients with either major depressive disorder (MDD) and/or T2D. PATIENTS AND METHODS: In this study, we analyzed 6 variants within the PRL gene and tested them for the presence of parametric linkage and/or linkage disequilibrium (LD, i.e., linkage and association) with familial MDD, T2D, and their comorbidity. RESULTS: We found, for the first time, that the PRL gene and its novel risk variants are linked to and in LD (i.e., linkage and association) with familial MDD, T2D, and MDD-T2D comorbidity. CONCLUSIONS: PRL might play a key role in mental-metabolic comorbidity and can be considered a novel gene in MDD and T2D.
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U2 - 10.26355/eurrev_202305_32315
DO - 10.26355/eurrev_202305_32315
M3 - Article
C2 - 37203833
AN - SCOPUS:85159768210
SN - 1128-3602
VL - 27
SP - 4080
EP - 4084
JO - European Review for Medical and Pharmacological Sciences
JF - European Review for Medical and Pharmacological Sciences
IS - 9
ER -
