Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure

Michael A. Makara, Jerry Curran, Ellen R. Lubbers, Nathaniel P. Murphy, Sean C. Little, Hassan Musa, Sakima A. Smith, Sathya D. Unudurthi, Murugesan V.S. Rajaram, Paul M.L. Janssen, Penelope A. Boyden, Elisa A. Bradley, Thomas J. Hund, Peter J. Mohler

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Ankyrin polypeptides are intracellular proteins responsible for targeting cardiac membrane proteins. Here, the authors demonstrate that ankyrin-G plays an unexpected role in normal compensatory physiological remodeling in response to myocardial stress and aging; the authors implicate disruption of ankyrin-G in human heart failure. Mechanistically, the authors illustrate that ankyrin-G serves as a key nodal protein required for cardiac myofilament integration with the intercalated disc. Their data define novel in vivo mechanistic roles for ankyrin-G, implicate ankyrin-G as necessary for compensatory cardiac physiological remodeling under stress, and implicate disruption of ankyrin-G in the development and progression of human heart failure.

Original languageEnglish (US)
Pages (from-to)675-689
Number of pages15
JournalJACC: Basic to Translational Science
Volume3
Issue number5
DOIs
StatePublished - Oct 2018

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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