@article{eeafe4e5eb584dd6ad392fd8a07b4a22,
title = "Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure",
abstract = "Ankyrin polypeptides are intracellular proteins responsible for targeting cardiac membrane proteins. Here, the authors demonstrate that ankyrin-G plays an unexpected role in normal compensatory physiological remodeling in response to myocardial stress and aging; the authors implicate disruption of ankyrin-G in human heart failure. Mechanistically, the authors illustrate that ankyrin-G serves as a key nodal protein required for cardiac myofilament integration with the intercalated disc. Their data define novel in vivo mechanistic roles for ankyrin-G, implicate ankyrin-G as necessary for compensatory cardiac physiological remodeling under stress, and implicate disruption of ankyrin-G in the development and progression of human heart failure.",
author = "Makara, {Michael A.} and Jerry Curran and Lubbers, {Ellen R.} and Murphy, {Nathaniel P.} and Little, {Sean C.} and Hassan Musa and Smith, {Sakima A.} and Unudurthi, {Sathya D.} and Rajaram, {Murugesan V.S.} and Janssen, {Paul M.L.} and Boyden, {Penelope A.} and Bradley, {Elisa A.} and Hund, {Thomas J.} and Mohler, {Peter J.}",
note = "Funding Information: This work is supported by the Ohio State JB Project and Healing Hearts of Central Ohio. The authors are supported by NIH grants HL135754, HL134824, HL139348, HL135096, and HL114383 (Dr. Mohler), HL135437 (Dr. Smith), HL135096, HL134824, and HL114893 (Dr. Hund), HL137331 (Ms. Lubbers), and HL137325 (Mr. Murphy). Dr. Makara has been employed by DOCS Global (CRO) as a medical writer contracting for Merck Sharpe & Dohme Corp. Dr. Curran has been an employee of Abiomed. Dr. Little has been employed by Bristol-Myers Squibb. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2018",
month = oct,
doi = "10.1016/j.jacbts.2018.07.008",
language = "English (US)",
volume = "3",
pages = "675--689",
journal = "JACC: Basic to Translational Science",
issn = "2452-302X",
publisher = "Elsevier Inc.",
number = "5",
}