Novel targets and stimulation paradigms for deep brain stimulation

Sol De Jesus, Leonardo Almeida, Zhongxing Peng-Chen, Michael S. Okun, Christopher W. Hess

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Deep brain stimulation (DBS) is an accepted therapy for appropriately selected patients with movement disorders and psychiatric disease. The recent advances in lead technology and the advent of novel stimulation parameters have spurred a number of improvements that will likely be implemented in the clinical setting. Although the mechanisms and biology of DBS remain poorly understood, the progress in our understanding of network level dysfunction has driven the introduction of a variety of new targets and approaches to the treatment of human disease. Here we summarize the recent advances in novel stimulation patterns and customized field shaping. We also review new targets, novel applications of DBS and the immediate and long-term horizon for this therapy.

Original languageEnglish (US)
Pages (from-to)1067-1080
Number of pages14
JournalExpert Review of Neurotherapeutics
Issue number9
StatePublished - Sep 2 2015

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Clinical Neurology
  • Pharmacology (medical)


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