TY - JOUR
T1 - Nuclear DNA as Predictor of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft
T2 - A Pilot Study
AU - Likhvantsev, Valery V.
AU - Landoni, Giovanni
AU - Grebenchikov, Oleg A.
AU - Skripkin, Yuri V.
AU - Zabelina, Tatiana S.
AU - Zinovkina, Liudmila A.
AU - Prikhodko, Anastasia S.
AU - Lomivorotov, Vladimir V.
AU - Zinovkin, Roman A.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/12
Y1 - 2017/12
N2 - Objective To measure the release of plasma nuclear deoxyribonucleic acid (DNA) and to assess the relationship between nuclear DNA level and acute kidney injury occurrence in patients undergoing cardiac surgery. Setting Cardiovascular anesthesiology and intensive care unit of a large tertiary-care university hospital. Design Prospective observational study. Participants Fifty adult patients undergoing cardiac surgery. Interventions Nuclear DNA concentration was measured in the plasma. The relationship between the level of nuclear DNA and the incidence of acute kidney injury after coronary artery bypass grafting was investigated. Measurements and Main Results Cardiac surgery leads to significant increase in plasma nuclear DNA with peak levels 12 hours after surgery (median [interquartile range] 7.0 [9.6-22.5] µg/mL). No difference was observed between off-pump and on-pump surgical techniques. Nuclear DNA was the only predictor of acute kidney injury between baseline and early postoperative risk factors. Conclusions The authors found an increase of nuclear DNA in the plasma of patients who had undergone coronary artery bypass grafting, with a peak after 12 hours and an association of nuclear DNA with postoperative acute kidney injury.
AB - Objective To measure the release of plasma nuclear deoxyribonucleic acid (DNA) and to assess the relationship between nuclear DNA level and acute kidney injury occurrence in patients undergoing cardiac surgery. Setting Cardiovascular anesthesiology and intensive care unit of a large tertiary-care university hospital. Design Prospective observational study. Participants Fifty adult patients undergoing cardiac surgery. Interventions Nuclear DNA concentration was measured in the plasma. The relationship between the level of nuclear DNA and the incidence of acute kidney injury after coronary artery bypass grafting was investigated. Measurements and Main Results Cardiac surgery leads to significant increase in plasma nuclear DNA with peak levels 12 hours after surgery (median [interquartile range] 7.0 [9.6-22.5] µg/mL). No difference was observed between off-pump and on-pump surgical techniques. Nuclear DNA was the only predictor of acute kidney injury between baseline and early postoperative risk factors. Conclusions The authors found an increase of nuclear DNA in the plasma of patients who had undergone coronary artery bypass grafting, with a peak after 12 hours and an association of nuclear DNA with postoperative acute kidney injury.
UR - http://www.scopus.com/inward/record.url?scp=85029909531&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029909531&partnerID=8YFLogxK
U2 - 10.1053/j.jvca.2017.04.051
DO - 10.1053/j.jvca.2017.04.051
M3 - Article
C2 - 28967626
AN - SCOPUS:85029909531
SN - 1053-0770
VL - 31
SP - 2080
EP - 2085
JO - Journal of cardiothoracic and vascular anesthesia
JF - Journal of cardiothoracic and vascular anesthesia
IS - 6
ER -