Nuclear magnetic resonance in the era of structural genomics

J. H. Prestegard, H. Valafar, J. Glushka, F. Tian

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Current interests in structural genomics, and the associated need for high through-put structure determination methods, offer an opportunity to examine new nuclear magnetic resonance (NMR) methodology and the impact this methodology can have on structure determination of proteins. The time required for structure determination by traditional NMR methods is currently long, but improved hardware, automation of analysis, and new sources of data such as residual dipolar couplings promise to change this. Greatly improved efficiency, coupled with an ability to characterize proteins that may not produce crystals suitable for investigation by X-ray diffraction, suggests that NMR will play an important role in structural genomics programs.

Original languageEnglish (US)
Pages (from-to)8677-8685
Number of pages9
Issue number30
StatePublished - Jul 31 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry


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