TY - JOUR
T1 - Nucleosome structural studies
AU - Tan, Song
AU - Davey, Curt A.
N1 - Funding Information:
We are grateful to the Davey and the Tan laboratories for stimulating discussions. This work was supported by Academic Research Council grant 19/08 from the Ministry of Education (Singapore) to CAD and US National Institutes of Health grant GM088236 to ST.
PY - 2011/2
Y1 - 2011/2
N2 - Chromatin plays a fundamental role in eukaryotic genomic regulation, and the increasing awareness of the importance of epigenetic processes in human health and disease emphasizes the need for understanding the structure and function of the nucleosome. Recent advances in chromatin structural studies, including the first structures of nucleosomes containing the Widom 601 sequence and the structure of a chromatin protein-nucleosome assembly, have provided new insight into stretching of nucleosomal DNA, nucleosome positioning, binding of metal ions, drugs and therapeutic candidates to nucleosomes, and nucleosome recognition by nuclear proteins. These discoveries ensure promising future prospects for unravelling structural attributes of chromatin.
AB - Chromatin plays a fundamental role in eukaryotic genomic regulation, and the increasing awareness of the importance of epigenetic processes in human health and disease emphasizes the need for understanding the structure and function of the nucleosome. Recent advances in chromatin structural studies, including the first structures of nucleosomes containing the Widom 601 sequence and the structure of a chromatin protein-nucleosome assembly, have provided new insight into stretching of nucleosomal DNA, nucleosome positioning, binding of metal ions, drugs and therapeutic candidates to nucleosomes, and nucleosome recognition by nuclear proteins. These discoveries ensure promising future prospects for unravelling structural attributes of chromatin.
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U2 - 10.1016/j.sbi.2010.11.006
DO - 10.1016/j.sbi.2010.11.006
M3 - Review article
C2 - 21176878
AN - SCOPUS:79551685899
SN - 0959-440X
VL - 21
SP - 128
EP - 136
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 1
ER -
