@article{656d840410464584911052b66137c135,
title = "Nucleotide sequence of hamster S-adenosylmethionine decarboxylase cDNA",
abstract = "The nucleotide sequence of a cDNA encoding the proenzyme of hamster S-adenosylmethionine decarboxylase including 169 nucleotides of the 5′ untranslated region has been determined. The deduced amino acid sequence shows a remarkable similarity to the human proenzyme with only seven differences out of 334 amino acids. The nucleotide sequence of the 5′ untranslated region showed 93% homology with the corresponding rat and human sequences suggesting that this region may play an important role in the regulation of S-adenosylmethionine decarboxylase expression.",
author = "Tekwani, {Babu L.} and Bruce Stanley and Anthony Pegg",
note = "Funding Information: The nucleotide sequence of the coding region of the hamster AdoMetDC cDNA exhibited > 95% homology with the human sequence with changes only at 42 locations and > 97% homology with the rat sequence showing differences only at 31 locations. When the deduced amino acid sequence of hamster AdoMetDC proenzyme was compared with human and rat equivalents, the hamster sequence showed seven amino acid differences with the human sequence and only three differences with the rat sequence, indicating that most of the differences observed in the nucleotide sequence were silent (Fig. 2). it is apparent from Fig. 2 that there i,,~ very great conservation of the amino acid sequence of the AdoMetDC proenzyme in these mammalian species. Only ten of the positions show any changes. The high level of conservation of the AdoMetDC sequence may reflect the multiple functions of the protein which include the autocatalytic processing of the proenzyme, enzymatic activity, regulation by putrescine and rapid protein turnover. This research was supported by grants CA18138 and 11=05 TW044006.01 (an international fellowship award to BLT by Fogarty International Center) from the National Institutes of Health, USA.",
year = "1992",
month = mar,
day = "24",
doi = "10.1016/0167-4781(92)90533-6",
language = "English (US)",
volume = "1130",
pages = "221--223",
journal = "BBA - Gene Structure and Expression",
issn = "0167-4781",
publisher = "Elsevier B.V.",
number = "2",
}